Implication of ivabradine in up-titrating beta-blocker in a patient with advanced heart failure

Masakazu Hori, Teruhiko Imamura*, Makiko Nakamura, Koichiro Kinugawa

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

5 被引用数 (Scopus)

抄録

Titration of beta-blockers is a gold-standard therapy in patients with heart failure and a reduced ejection fraction but is sometimes challenging to administer, given symptomatic hypotension. Ivabradine is a recently introduced selective If channel inhibitor that purely reduces the heart rate. We encountered a patient with advanced heart failure in whom a beta-blocker could not be up-titrated given his symptomatic hypotension. Following the initiation of ivabradine, an increase in blood pressure due to heart rate optimization, probably via an improvement in the cardiac output, allowed for the further up-titration of carvedilol, followed by a successful clinical course. Ivabradine might be a novel therapeutic tool to facilitate the up-titration of beta-blockers in patients with heart failure and hypotension.

本文言語英語
ページ(範囲)897-900
ページ数4
ジャーナルInternal Medicine
60
6
DOI
出版ステータス出版済み - 2021

ASJC Scopus 主題領域

  • 内科学

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