Impact of plasma volume status on mortality following left ventricular assist device implantation

Teruhiko Imamura*, Nikhil Narang, Pamela Combs, Umar Siddiqi, Saeid Mirzai, Corinne Stonebraker, Heather Bullard, Pamela Simone, Valluvan Jeevanandam

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

3 被引用数 (Scopus)

抄録

Worsening systemic congestion is often the central trigger of hospitalization in patients with heart failure. However, accurate assessment of congestion is challenging. The prognostic impact of systemic congestion following durable continuous-flow left ventricular assist device (LVAD) implantation remains unknown. Consecutive patients who received durable continuous-flow LVAD implantation between January 2014 and June 2017 and were followed for 1 year were included. The association of preoperative plasma volume status, which was calculated using patients’ body weight and hematocrit and expressed as a deviation from ideal plasma volume, with 1-year mortality following LVAD implantation was investigated. In total, 186 patients (median 57 years and 138 males) were included. Baseline plasma volume status was −30.1% (−37.1%, −19.4%) on median. Eighty-eight patients (47%) had higher plasma volume status (>−29.8%), and their 1-year survival was significantly lower than those without (67% vs. 87%, P =.001). High plasma volume status was an independent predictor of 1-year death with an adjusted hazard ratio of 4.52 (95% confidence interval 1.52-13.5). Baseline systemic congestion, as defined by the high plasma volume status, was associated with higher mortality following durable continuous-flow LVAD implantation. The implication of improving preoperative plasma volume remains an area of needed investigation.

本文言語英語
ページ(範囲)587-592
ページ数6
ジャーナルArtificial Organs
45
6
DOI
出版ステータス出版済み - 2021/06

ASJC Scopus 主題領域

  • バイオエンジニアリング
  • 医学(その他)
  • 生体材料
  • 生体医工学

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