@article{4fd731ff0be74e9c881afbba347c4d50,
title = "Identification and characterization of zebrafish semaphorin 6D",
abstract = "The semaphorin gene family contains a large number of secreted and transmembrane proteins; some function as repulsive and attractive cues of axon guidance during development. Here, we report cloning and characterization of zebrafish transmembrane semaphorin gene, semaphorin 6D (sema6D). Sema6D is expressed predominantly in the nervous system during embryogenesis, as determined by in situ hybridization. We also found that Sema6D binds Plexin-A1 in vitro, but not other Plexins. It induces the repulsion of dorsal root ganglion axons, but not sympathetic axons. Consequently, Sema6D might use Plexin-A1 as a receptor to repel specific types of axons during development.",
keywords = "Axon guidance, Brain, Lens, Plexin, Repellent, Rhombomere, Semaphorin",
author = "Masafumi Kimura and Masahiko Taniguchi and Yoshinori Mikami and Tomoyuki Masuda and Tomoyuki Yoshida and Masayoshi Mishina and Takao Shimizu",
note = "Funding Information: We are grateful to Dr. Hitoshi Okamoto (RIKEN, BSI) for the gift of zebrafish Plexin-A4 expression vector and krox-20 vector, and Naoka Taniguchi (The University of Tokyo) for helpful assistance. This work was supported by Grants-in-Aid for Scientific Research on Priority Area—Elucidation of neural network function in the brain- from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Y.M. is a Research Fellow of the Japan Society for the Promotion of Science. ",
year = "2007",
month = nov,
day = "23",
doi = "10.1016/j.bbrc.2007.09.038",
language = "英語",
volume = "363",
pages = "762--768",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier B.V.",
number = "3",
}