Huperphlegmines A and B, two novel Lycopodium alkaloids with an unprecedented skeleton from Huperzia phlegmaria, and their acetylcholinesterase inhibitory activities

Hoai Thi Nguyen; Huong Thi Doan; Duc Viet Ho; Ky Thanh Pham; Ain Raal; Hiroyuki Morita

doi:10.1016/j.fitote.2018.07.016

Huperphlegmines A and B, two novel Lycopodium alkaloids with an unprecedented skeleton from Huperzia phlegmaria, and their acetylcholinesterase inhibitory activities

Hoai Thi Nguyen, Huong Thi Doan, Duc Viet Ho, Ky Thanh Pham, Ain Raal^*, Hiroyuki Morita

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

18 被引用数 (Scopus)

抄録

Two novel Lycopodium alkaloids, huperphlegmines A and B (1 and 2), were isolated from the aerial parts of Huperzia phlegmaria collected in Vietnam, together with the five known compounds lycophlegmariol A (3), phlegmariurine B (4), 5-hydroxymethyl-2-furaldehyde (5), rhemanone C (6), and loliolide (7). The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparisons to the reported data in the literature. Compounds 1 and 2 showed moderate acetylcholinesterase inhibitory activities, with IC₅₀ values of 25.95 ± 0.67 and 29.14 ± 0.77 μg/mL, respectively.

本文言語	英語
ページ（範囲）	267-271
ページ数	5
ジャーナル	Fitoterapia
巻	129
DOI	https://doi.org/10.1016/j.fitote.2018.07.016
出版ステータス	出版済み - 2018/09

ASJC Scopus 主題領域

薬理学
創薬

文献へのアクセス

10.1016/j.fitote.2018.07.016

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引用スタイル

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title = "Huperphlegmines A and B, two novel Lycopodium alkaloids with an unprecedented skeleton from Huperzia phlegmaria, and their acetylcholinesterase inhibitory activities",

abstract = "Two novel Lycopodium alkaloids, huperphlegmines A and B (1 and 2), were isolated from the aerial parts of Huperzia phlegmaria collected in Vietnam, together with the five known compounds lycophlegmariol A (3), phlegmariurine B (4), 5-hydroxymethyl-2-furaldehyde (5), rhemanone C (6), and loliolide (7). The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparisons to the reported data in the literature. Compounds 1 and 2 showed moderate acetylcholinesterase inhibitory activities, with IC50 values of 25.95 ± 0.67 and 29.14 ± 0.77 μg/mL, respectively.",

keywords = "Acetylcholinesterase inhibitory activity, Huperphlegmine, Huperzia phlegmaria, Lycopodium alkaloid",

author = "Nguyen, {Hoai Thi} and Doan, {Huong Thi} and Ho, {Duc Viet} and Pham, {Ky Thanh} and Ain Raal and Hiroyuki Morita",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = sep,

doi = "10.1016/j.fitote.2018.07.016",

language = "英語",

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TY - JOUR

T1 - Huperphlegmines A and B, two novel Lycopodium alkaloids with an unprecedented skeleton from Huperzia phlegmaria, and their acetylcholinesterase inhibitory activities

AU - Nguyen, Hoai Thi

AU - Doan, Huong Thi

AU - Ho, Duc Viet

AU - Pham, Ky Thanh

AU - Raal, Ain

AU - Morita, Hiroyuki

PY - 2018/9

Y1 - 2018/9

N2 - Two novel Lycopodium alkaloids, huperphlegmines A and B (1 and 2), were isolated from the aerial parts of Huperzia phlegmaria collected in Vietnam, together with the five known compounds lycophlegmariol A (3), phlegmariurine B (4), 5-hydroxymethyl-2-furaldehyde (5), rhemanone C (6), and loliolide (7). The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparisons to the reported data in the literature. Compounds 1 and 2 showed moderate acetylcholinesterase inhibitory activities, with IC50 values of 25.95 ± 0.67 and 29.14 ± 0.77 μg/mL, respectively.

AB - Two novel Lycopodium alkaloids, huperphlegmines A and B (1 and 2), were isolated from the aerial parts of Huperzia phlegmaria collected in Vietnam, together with the five known compounds lycophlegmariol A (3), phlegmariurine B (4), 5-hydroxymethyl-2-furaldehyde (5), rhemanone C (6), and loliolide (7). The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparisons to the reported data in the literature. Compounds 1 and 2 showed moderate acetylcholinesterase inhibitory activities, with IC50 values of 25.95 ± 0.67 and 29.14 ± 0.77 μg/mL, respectively.

KW - Acetylcholinesterase inhibitory activity

KW - Huperphlegmine

KW - Huperzia phlegmaria

KW - Lycopodium alkaloid

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U2 - 10.1016/j.fitote.2018.07.016

DO - 10.1016/j.fitote.2018.07.016

M3 - 学術論文

C2 - 30056186

AN - SCOPUS:85050679364

SN - 0367-326X

VL - 129

SP - 267

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JO - Fitoterapia

JF - Fitoterapia

ER -