Hippocampal-amygdala memory circuits govern experience-dependent observational fear

Joseph I. Terranova, Jun Yokose, Hisayuki Osanai, William D. Marks, Jun Yamamoto, Sachie K. Ogawa, Takashi Kitamura*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

58 被引用数 (Scopus)

抄録

The empathic ability to vicariously experience the other's fearful situation, a process called observational fear (OF), is critical to survive in nature and function in society. OF can be facilitated by both prior similar fear experience in the observer and social familiarity with the demonstrator. However, the neural circuit mechanisms of experience-dependent OF (Exp OF) remain unknown. Here, we demonstrate that hippocampal-basolateral amygdala (HPC-BLA) circuits in mice without involving the anterior cingulate cortex, considered a center of OF, mediate Exp OF. Dorsal HPC neurons generate fear memory engram cells in BLA encoding prior similar fear experiences, which are essential for Exp OF. On the other hand, ventral HPC neurons respond to the familiar demonstrator's aversive situation during Exp OF, which reactivates the fear memory engram cells in BLA to elicit Exp OF. Our study provides new insights into the memory engram-dependent perception-action coupling that underlies empathic behaviors like Exp OF.

本文言語英語
ページ(範囲)1416-1431.e13
ジャーナルNeuron
110
8
DOI
出版ステータス出版済み - 2022/04/20

ASJC Scopus 主題領域

  • 神経科学一般

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