TY - JOUR
T1 - Highly active copper(i) complexes of aroylthiourea ligands against cancer cells-synthetic and biological studies
AU - Jeyalakshmi, Kumaramangalam
AU - Haribabu, Jebiti
AU - Balachandran, Chandrasekar
AU - Narmatha, Eswaramoorthi
AU - Bhuvanesh, Nattamai S.P.
AU - Aoki, Shin
AU - Awale, Suresh
AU - Karvembu, Ramasamy
N1 - Publisher Copyright:
© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
PY - 2019
Y1 - 2019
N2 - The reaction of copper(i) bromide with aroylthiourea ligands (L) in the molar ratio 1 : 3 resulted in the formation of [CuBr(L)3]. The complexes were well characterized by analytical and spectroscopic (UV-visible, FT-IR, NMR and mass) techniques. Tetrahedral geometry of complexes 1 and 3 was confirmed by single crystal X-ray diffraction study. The interaction of complexes with biomolecules (DNA/protein) has been evaluated using spectrophotometric and spectrofluorometric techniques. The compounds were screened for their in vitro cytotoxicity against cancer and normal cell lines. Complexes 1 and 2 showed potent cytotoxic activity against HeLa cells with an IC50 value of 1.23 and 0.47 μM, respectively. Staining and colony formation studies were also carried out for the most active complexes to predict the morphological changes and colony formation ability, respectively.
AB - The reaction of copper(i) bromide with aroylthiourea ligands (L) in the molar ratio 1 : 3 resulted in the formation of [CuBr(L)3]. The complexes were well characterized by analytical and spectroscopic (UV-visible, FT-IR, NMR and mass) techniques. Tetrahedral geometry of complexes 1 and 3 was confirmed by single crystal X-ray diffraction study. The interaction of complexes with biomolecules (DNA/protein) has been evaluated using spectrophotometric and spectrofluorometric techniques. The compounds were screened for their in vitro cytotoxicity against cancer and normal cell lines. Complexes 1 and 2 showed potent cytotoxic activity against HeLa cells with an IC50 value of 1.23 and 0.47 μM, respectively. Staining and colony formation studies were also carried out for the most active complexes to predict the morphological changes and colony formation ability, respectively.
UR - http://www.scopus.com/inward/record.url?scp=85061360918&partnerID=8YFLogxK
U2 - 10.1039/c8nj04246b
DO - 10.1039/c8nj04246b
M3 - 学術論文
AN - SCOPUS:85061360918
SN - 1144-0546
VL - 43
SP - 3188
EP - 3198
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 7
ER -