@article{69955b0dc248465cb1694434bfaffe1b,
title = "Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization",
abstract = "During fasting, animals maintain their energy balance by shifting their energy source from carbohydrates to triglycerides. However, the trigger for this switch has not yet been entirely elucidated. Here we show that a selective hepatic vagotomy slows the speed of fat consumption by attenuating sympathetic nerve-mediated lipolysis in adipose tissue. Hepatic glycogen pre-loading by the adenoviral overexpression of glycogen synthase or the transcription factor TFE3 abolished this liver-brain-adipose axis activation. Moreover, the blockade of glycolysis through the knockdown of the glycogen phosphorylase gene and the resulting elevation in the glycogen content abolished the lipolytic signal from the liver, indicating that glycogen is the key to triggering this neurocircuitry. These results demonstrate that liver glycogen shortage activates a liver-brain-adipose neural axis that has an important role in switching the fuel source from glycogen to triglycerides under prolonged fasting conditions.",
author = "Yoshihiko Izumida and Naoya Yahagi and Yoshinori Takeuchi and Makiko Nishi and Akito Shikama and Ayako Takarada and Yukari Masuda and Midori Kubota and Takashi Matsuzaka and Yoshimi Nakagawa and Yoko Iizuka and Keiji Itaka and Kazunori Kataoka and Seiji Shioda and Akira Niijima and Tetsuya Yamada and Hideki Katagiri and Ryozo Nagai and Nobuhiro Yamada and Takashi Kadowaki and Hitoshi Shimano",
note = "Funding Information: This work was supported by Grants-in-aid from the Ministry of Science, Education, Culture and Technology of Japan (to Y.I. and N.Y.), especially by a MEXT Grant-in-Aid Project (Scientific Research on Innovative Areas) {\textquoteleft}Crosstalk between transcriptional control and energy pathways, mediated by hub metabolites{\textquoteright} (to N.Y.). It was also supported by research Grants from the Uehara Memorial Foundation, ONO Medical Research Foundation, Takeda Science Foundation, Suzuken Memorial Foundation, Japan Heart Foundation, Kanae Foundation for the Promotion of Medical Science, Senri Life Science Foundation, Japan Diabetes Foundation, Japan Foundation for Applied Enzymology and Okinaka Memorial Institute for Medical Research (to N.Y.).",
year = "2013",
doi = "10.1038/ncomms3316",
language = "英語",
volume = "4",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Research",
}