Function of K+-Cl- cotransporters in the acid secretory mechanism of gastric parietal cells

Takuto Fujii; Kyosuke Fujita; Noriaki Takeguchi; Hideki Sakai

doi:10.1248/bpb.34.810

Function of K⁺-Cl^- cotransporters in the acid secretory mechanism of gastric parietal cells

Takuto Fujii^*, Kyosuke Fujita, Noriaki Takeguchi, Hideki Sakai

^*この論文の責任著者

薬物生理学研究室

研究成果: ジャーナルへの寄稿 › 総説 › 査読

13 被引用数 (Scopus)

抄録

Gastric proton pump (H⁺,K⁺-ATPase) secretes H ⁺ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl^-- and K⁺-transporting proteins are required. Recent our studies have demonstrated that K⁺-Cl^- cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na⁺,K⁺-ATPase in the basolateral membrane, and KCC4 is associated with H⁺,K⁺-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.

本文言語	英語
ページ（範囲）	810-812
ページ数	3
ジャーナル	Biological and Pharmaceutical Bulletin
巻	34
号	6
DOI	https://doi.org/10.1248/bpb.34.810
出版ステータス	出版済み - 2011/06

ASJC Scopus 主題領域

薬理学
薬科学

文献へのアクセス

10.1248/bpb.34.810

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title = "Function of K+-Cl- cotransporters in the acid secretory mechanism of gastric parietal cells",

abstract = "Gastric proton pump (H+,K+-ATPase) secretes H + of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl-- and K+-transporting proteins are required. Recent our studies have demonstrated that K+-Cl- cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na+,K+-ATPase in the basolateral membrane, and KCC4 is associated with H+,K+-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.",

keywords = "Gastric acid secretion, Gastric parietal cell, H, K-atpase, K-clcotransporter, Na",

author = "Takuto Fujii and Kyosuke Fujita and Noriaki Takeguchi and Hideki Sakai",

year = "2011",

month = jun,

doi = "10.1248/bpb.34.810",

language = "英語",

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AU - Fujii, Takuto

AU - Fujita, Kyosuke

AU - Takeguchi, Noriaki

AU - Sakai, Hideki

PY - 2011/6

Y1 - 2011/6

N2 - Gastric proton pump (H+,K+-ATPase) secretes H + of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl-- and K+-transporting proteins are required. Recent our studies have demonstrated that K+-Cl- cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na+,K+-ATPase in the basolateral membrane, and KCC4 is associated with H+,K+-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.

AB - Gastric proton pump (H+,K+-ATPase) secretes H + of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl-- and K+-transporting proteins are required. Recent our studies have demonstrated that K+-Cl- cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na+,K+-ATPase in the basolateral membrane, and KCC4 is associated with H+,K+-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.

KW - Gastric acid secretion

KW - Gastric parietal cell

KW - H

KW - K-atpase

KW - K-clcotransporter

KW - Na

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DO - 10.1248/bpb.34.810

M3 - 総説

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SN - 0918-6158

VL - 34

SP - 810

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JO - Biological and Pharmaceutical Bulletin

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Function of K+-Cl- cotransporters in the acid secretory mechanism of gastric parietal cells

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ASJC Scopus 主題領域

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引用スタイル

Function of K⁺-Cl^- cotransporters in the acid secretory mechanism of gastric parietal cells