Flavonoid glycosides from Chromolaena odorata leaves and their in vitro cytotoxic activity

Tran Manh Hung; To Dao Cuong; Nguyen Hai Dang; Shu Zhu; Pham Quoc Long; Katsuko Komatsu; Byung Sun Min

doi:10.1248/cpb.59.129

Flavonoid glycosides from Chromolaena odorata leaves and their in vitro cytotoxic activity

Tran Manh Hung, To Dao Cuong, Nguyen Hai Dang, Shu Zhu, Pham Quoc Long, Katsuko Komatsu, Byung Sun Min

和漢医薬学総合研究所研究開発部門資源開発分野（資源科学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

36 被引用数 (Scopus)

抄録

Two new flavonoid glycosides, (1, 2), and eleven known compounds, (3-13), were isolated from from a 70% EtOH extract of the leaves of Chromolaena odorata (Asteraceae). Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The newly isolated compounds were tested in vitro for their cytotoxic activities against the LLC and HL-60 cancer cell lines. Compound 1 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC₅₀ values of 28.2 and 11.6 μM, respectively. Compound 2 exhibited significant cytotoxic activity in the inhibition of HL-60 cancer cell lines with IC₅₀ value of 10.8 μM.

本文言語	英語
ページ（範囲）	129-131
ページ数	3
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	59
号	1
DOI	https://doi.org/10.1248/cpb.59.129
出版ステータス	出版済み - 2011/01

ASJC Scopus 主題領域

化学一般
創薬

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10.1248/cpb.59.129

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title = "Flavonoid glycosides from Chromolaena odorata leaves and their in vitro cytotoxic activity",

abstract = "Two new flavonoid glycosides, (1, 2), and eleven known compounds, (3-13), were isolated from from a 70% EtOH extract of the leaves of Chromolaena odorata (Asteraceae). Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The newly isolated compounds were tested in vitro for their cytotoxic activities against the LLC and HL-60 cancer cell lines. Compound 1 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC50 values of 28.2 and 11.6 μM, respectively. Compound 2 exhibited significant cytotoxic activity in the inhibition of HL-60 cancer cell lines with IC50 value of 10.8 μM.",

keywords = "Asteraceae, Chromolaena odorata, Cytotoxic, Flavonoid glycoside",

author = "Hung, {Tran Manh} and Cuong, {To Dao} and Dang, {Nguyen Hai} and Shu Zhu and Long, {Pham Quoc} and Katsuko Komatsu and Min, {Byung Sun}",

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doi = "10.1248/cpb.59.129",

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T1 - Flavonoid glycosides from Chromolaena odorata leaves and their in vitro cytotoxic activity

AU - Hung, Tran Manh

AU - Cuong, To Dao

AU - Dang, Nguyen Hai

AU - Zhu, Shu

AU - Long, Pham Quoc

AU - Komatsu, Katsuko

AU - Min, Byung Sun

PY - 2011/1

Y1 - 2011/1

N2 - Two new flavonoid glycosides, (1, 2), and eleven known compounds, (3-13), were isolated from from a 70% EtOH extract of the leaves of Chromolaena odorata (Asteraceae). Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The newly isolated compounds were tested in vitro for their cytotoxic activities against the LLC and HL-60 cancer cell lines. Compound 1 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC50 values of 28.2 and 11.6 μM, respectively. Compound 2 exhibited significant cytotoxic activity in the inhibition of HL-60 cancer cell lines with IC50 value of 10.8 μM.

AB - Two new flavonoid glycosides, (1, 2), and eleven known compounds, (3-13), were isolated from from a 70% EtOH extract of the leaves of Chromolaena odorata (Asteraceae). Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The newly isolated compounds were tested in vitro for their cytotoxic activities against the LLC and HL-60 cancer cell lines. Compound 1 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC50 values of 28.2 and 11.6 μM, respectively. Compound 2 exhibited significant cytotoxic activity in the inhibition of HL-60 cancer cell lines with IC50 value of 10.8 μM.

KW - Asteraceae

KW - Chromolaena odorata

KW - Cytotoxic

KW - Flavonoid glycoside

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U2 - 10.1248/cpb.59.129

DO - 10.1248/cpb.59.129

M3 - 学術論文

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AN - SCOPUS:78650835868

SN - 0009-2363

VL - 59

SP - 129

EP - 131

JO - Chemical and Pharmaceutical Bulletin

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Flavonoid glycosides from Chromolaena odorata leaves and their in vitro cytotoxic activity

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