TY - JOUR
T1 - First-Line, Non-Criterial Antiphospholipid Antibody Testing for the Diagnosis of Antiphospholipid Syndrome in Clinical Practice
T2 - A Combination of Anti–β2-Glycoprotein I Domain I and Anti–Phosphatidylserine/Prothrombin Complex Antibodies Tests
AU - Nakamura, Hiroyuki
AU - Oku, Kenji
AU - Amengual, Olga
AU - Ohmura, Kazumasa
AU - Fujieda, Yuichiro
AU - Kato, Masaru
AU - Bohgaki, Toshiyuki
AU - Yasuda, Shinsuke
AU - Atsumi, Tatsuya
N1 - Publisher Copyright:
© 2017, American College of Rheumatology
PY - 2018/4
Y1 - 2018/4
N2 - Objective: To assess the value of a combination of anti–β2-glycoprotein I (anti-β2GPI) domain I antibody and anti–phosphatidylserine/prothrombin complex (anti-PS/PT) antibody tests for the diagnosis of antiphospholipid syndrome (APS). Methods: This cross-sectional study involved a cohort of the patients who visited our clinic from April 2005 to March 2013. Tests for anti-β2GPI domain I antibodies, IgG anti-PS/PT antibodies, and IgM anti-PS/PT antibodies, together with tests for criteria-defined antiphospholipid antibodies (aPL), were performed in all patients. The total antiphospholipid score (aPL-S) was calculated for each patient according to titers of and positivity for aPL. Results: The study enrolled 157 patients (51 patients with APS and 106 with non-APS autoimmune diseases). All 21 patients positive for both anti-β2GPI domain I antibodies and IgG and/or IgM (IgG/IgM) anti-PS/PT antibodies had APS with a high total aPL-S (median 46, range 26–76), as did all of the 10 patients who were positive for anti-β2GPI domain I antibodies but negative for IgG/IgM anti-PS/PT antibodies (median 22, range 4–39). Of the 14 patients who were positive for IgG/IgM anti-PS/PT antibodies but negative for anti-β2GPI domain I antibodies, 11 (79%) had APS; these individuals also had high total aPL-S values (median 23, range 11–60). In contrast, only 9 of the 112 patients (8%) with none of these antibodies had APS. Conclusion: The combination of the IgG anti–β2GPI domain I antibody and IgG/IgM anti-PS/PT antibody tests shows a high positive predictive value for the diagnosis of APS and a strong correlation with the aPL-S. This combination as the first-line test for aPL may contribute to the simple and definite identification of APS with a high risk of thrombosis in clinical practice.
AB - Objective: To assess the value of a combination of anti–β2-glycoprotein I (anti-β2GPI) domain I antibody and anti–phosphatidylserine/prothrombin complex (anti-PS/PT) antibody tests for the diagnosis of antiphospholipid syndrome (APS). Methods: This cross-sectional study involved a cohort of the patients who visited our clinic from April 2005 to March 2013. Tests for anti-β2GPI domain I antibodies, IgG anti-PS/PT antibodies, and IgM anti-PS/PT antibodies, together with tests for criteria-defined antiphospholipid antibodies (aPL), were performed in all patients. The total antiphospholipid score (aPL-S) was calculated for each patient according to titers of and positivity for aPL. Results: The study enrolled 157 patients (51 patients with APS and 106 with non-APS autoimmune diseases). All 21 patients positive for both anti-β2GPI domain I antibodies and IgG and/or IgM (IgG/IgM) anti-PS/PT antibodies had APS with a high total aPL-S (median 46, range 26–76), as did all of the 10 patients who were positive for anti-β2GPI domain I antibodies but negative for IgG/IgM anti-PS/PT antibodies (median 22, range 4–39). Of the 14 patients who were positive for IgG/IgM anti-PS/PT antibodies but negative for anti-β2GPI domain I antibodies, 11 (79%) had APS; these individuals also had high total aPL-S values (median 23, range 11–60). In contrast, only 9 of the 112 patients (8%) with none of these antibodies had APS. Conclusion: The combination of the IgG anti–β2GPI domain I antibody and IgG/IgM anti-PS/PT antibody tests shows a high positive predictive value for the diagnosis of APS and a strong correlation with the aPL-S. This combination as the first-line test for aPL may contribute to the simple and definite identification of APS with a high risk of thrombosis in clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=85044655916&partnerID=8YFLogxK
U2 - 10.1002/acr.23310
DO - 10.1002/acr.23310
M3 - 学術論文
C2 - 28686816
AN - SCOPUS:85044655916
SN - 2151-464X
VL - 70
SP - 627
EP - 634
JO - Arthritis Care and Research
JF - Arthritis Care and Research
IS - 4
ER -