TY - JOUR
T1 - Factors enhancing serum syndecan-1 concentrations
T2 - A large-scale comprehensive medical examination
AU - Oda, Kazumasa
AU - Okada, Hideshi
AU - Suzuki, Akio
AU - Tomita, Hiroyuki
AU - Kobayashi, Ryo
AU - Sumi, Kazuyuki
AU - Suzuki, Kodai
AU - Takada, Chihiro
AU - Ishihara, Takuma
AU - Suzuki, Keiko
AU - Kano, Soichiro
AU - Kondo, Kohei
AU - Iwashita, Yuki
AU - Yano, Hirohisa
AU - Zaikokuji, Ryogen
AU - Sampei, So
AU - Fukuta, Tetsuya
AU - Kitagawa, Yuichiro
AU - Okamoto, Haruka
AU - Watanabe, Takatomo
AU - Kawaguchi, Tomonori
AU - Kojima, Takao
AU - Deguchi, Fumiko
AU - Miyazaki, Nagisa
AU - Yamada, Noriaki
AU - Doi, Tomoaki
AU - Yoshida, Takahiro
AU - Ushikoshi, Hiroaki
AU - Yoshida, Shozo
AU - Takemura, Genzou
AU - Ogura, Shinji
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/9
Y1 - 2019/9
N2 - Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018 to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by the collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (p = 0.016), aspartic aminotransferase concentration (AST, p = 0.020), blood urea nitrogen concentration (BUN, p = 0.013), triglyceride concentration (p < 0.001), and hematocrit (p = 0.006). These relationships were independent associations. Endothelial glycocalyx injury, which is reflected by serum syndecan-1 concentrations, is related to age, hematocrit, AST concentration, BUN concentration, and triglyceride concentration.
AB - Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018 to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by the collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (p = 0.016), aspartic aminotransferase concentration (AST, p = 0.020), blood urea nitrogen concentration (BUN, p = 0.013), triglyceride concentration (p < 0.001), and hematocrit (p = 0.006). These relationships were independent associations. Endothelial glycocalyx injury, which is reflected by serum syndecan-1 concentrations, is related to age, hematocrit, AST concentration, BUN concentration, and triglyceride concentration.
KW - Endothelial disorders
KW - Glycocalyx injury
KW - Nonlinear regression
KW - Syndecan-1
UR - http://www.scopus.com/inward/record.url?scp=85082054990&partnerID=8YFLogxK
U2 - 10.3390/jcm8091320
DO - 10.3390/jcm8091320
M3 - 学術論文
AN - SCOPUS:85082054990
SN - 2077-0383
VL - 8
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 9
M1 - 1320
ER -