Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor

Keyphrases

• Growth Factors 100%
• Insulin 100%
• Functional Role 100%
• Epidermal Growth Factor 100%
• Insulin-like 100%
• Mitogenic Signaling 100%
• Shc Proteins 100%
• Microinjection 40%
• Catalytic Activity 20%
• Fibroblasts 20%
• Fetal Calf Serum 20%
• Overexpressing 20%
• Bromodeoxyuridine 20%
• DNA Synthesis 20%
• Tyrosine Phosphorylation 20%
• Lysate 20%
• Cell Cycle Progression 20%
• Signal Transduction Pathway 20%
• Rat1 20%
• Constitutively Active 20%
• Immunoprecipitates 20%
• BrdU Incorporation 20%
• SH2 Domain 20%
• Activating Receptors 20%
• Ras Proteins 20%
• Human Insulin Receptor 20%
• Guanine nucleotide 20%
• Releasing Factors 20%
• Insulin Growth Factor 20%
• Quiescent Cells 20%

Biochemistry, Genetics and Molecular Biology

• Epidermal Growth Factor 100%
• Insulin-Like Growth Factor 1 100%
• Bromodeoxyuridine 40%
• Microinjection 40%
• P21 40%
• Growth Factor 20%
• Immunoprecipitation 20%
• Signal Transduction 20%
• DNA Synthesis 20%
• Insulin Receptor 20%
• Cell Lysate 20%
• Tyrosine Phosphorylation 20%
• Cell Cycle Progression 20%
• SH2 Domain 20%
• Fibroblast 20%
• Enzymatic Activity 20%
• Guanine 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Epidermal Growth Factor 100%
• Somatomedin C 100%
• Shc Signaling Adaptor Protein 100%
• Receptor 40%
• Broxuridine 40%
• Growth Factor 20%
• Ras Protein 20%
• Recombinant Human Insulin 20%
• Human Insulin 20%
• Somatomedin 20%
• Guanine Nucleotide 20%
• Releasing Factor 20%