Elastase-like enzyme in the aorta of spontaneously hypertensive rats

Eiji Yamada*, Fumitada Hazama, Hideo Kataoka, Shigeru Amano, Masakiyo Sasahara, Kalula Kayembe, Kouichi Katayama

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

15 被引用数 (Scopus)

抄録

In an attempt to obtain information regarding vascular elastase in arterial hypertension, we examined biochemical changes in elastase-like enzyme activity, and the intravascular localization of elastase by immunohistochemical techniques in the aorta of spontaneously hypertensive rats (SHR). In the biochemical study, aortic elastase-like enzyme activity was significantly higher in SHR than in controls. Using an antibody against rat pancreatic elastase raised in the rabbit, it was demonstrated immunohistochemically that the enzyme was localized in the endothelial cells and subendothelial spaces in the aorta of control animals. In SHR, elastase was also demonstrated in medial smooth muscle cells and particularly in the modified smooth muscle cells in areas of intimai thickening. Some vacuoles in the smooth muscle cells also showed positive enzyme staining. Elastase seems to play an important role in the development of hypertensive vascular changes.

本文言語英語
ページ(範囲)241-245
ページ数5
ジャーナルVirchows Archiv B Cell Pathology Including Molecular Pathology
44
1
DOI
出版ステータス出版済み - 1983/01

ASJC Scopus 主題領域

  • 病理学および法医学

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