Efficient Oxidative Cleavage of Tetrahydrofuran-2-methanols to γ-Lactones by a 2-Iodobenzamide Catalyst in Combination with Oxone®

Takayuki Yakura*, Yuto Horiuchi, Yushi Nishimura, Akihiro Yamada, Hisanori Nambu, Tomoya Fujiwara

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

17 被引用数 (Scopus)

抄録

An environmentally friendly oxidative cleavage of tetrahydrofuran-2-methanols to the corresponding γ-lactones using a catalytic amount of 2-iodo-N-isopropylbenzamide has been developed. The reaction of various tetrahydrofuran-2-methanols with the catalyst in the presence of Oxone® (2 KHSO5·KHSO4·K2SO4) as a co-oxidant in DMF at room temperature successfully affords the corresponding lactones in good to high yields, and recovery of the catalyst is readily accomplished using a reductive work-up. This method is notable because it enables the transformation of tetrahydrofuran-2-methanols to γ-lactones under mild conditions without the use of any toxic heavy metals.

本文言語英語
ページ(範囲)869-873
ページ数5
ジャーナルAdvanced Synthesis and Catalysis
358
6
DOI
出版ステータス出版済み - 2016/03/17

ASJC Scopus 主題領域

  • 触媒
  • 有機化学

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