Efficient one-pot tandem synthesis and cytotoxicity evaluation of 2,3-disubstituted quinazolin-4(3H)-one derivatives

Keyphrases

• Disubstituted 100%
• IC50 100%
• Synthetic Evaluation 100%
• One-pot Synthesis 100%
• Cytotoxicity Test 100%
• Quinazolin-4(3H)-one Derivatives 100%
• A549 Cells 66%
• Positive Control 66%
• 5-fluorouracil (5-FU) 66%
• Aldehydes 33%
• Good Yield 33%
• MCF-7 33%
• Cancer Cell Lines 33%
• IC50 Value 33%
• HeLa 33%
• Cytotoxic Activity 33%
• A549 33%
• Radiation Condition 33%
• MCF-7 Cells 33%
• Ring Opening 33%
• Moderate Activity 33%
• Cytotoxicity Assay 33%
• Oxidative Cyclization 33%
• Iodine-catalyzed 33%
• Tandem-ring 33%
• Isatoic Anhydride 33%
• Microwave Irradiation 33%

Pharmacology, Toxicology and Pharmaceutical Science

• IC50 100%
• Quinazoline 100%
• Cytotoxicity 100%
• Fluorouracil 50%
• Malignant Neoplasm 25%
• Cytotoxicity Assay 25%
• Acid Anhydride 25%
• Microwave Irradiation 25%

Chemistry

• IC50 100%
• 5-Fluorouracil 50%
• Ring Opening Reaction 25%
• Anhydride 25%
• Oxidative Cyclization 25%
• Microwave Irradiation 25%