Effects of halothane on membrane potentials and membrane ionic currents in single bullfrog atrial cells

K. Hirota, Y. Ito*, Y. Momose

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

14 被引用数 (Scopus)

抄録

Halothane exerts negative inotropic and negative chronotropic actions on the isolated heart in experimental animals. In order to assess directly the actions of halothane in myocardium, we studied the effects of halothane on membrane potentials and transmembrane ionic currents in single isolated frog atrial cells obtained by the enzymatic dissociation method. The results show: (a) that the action potential is prolonged and its plateau phase and overshoot are depressed, but the resting potential remains unchanged; (b) that there is a significant inhibition of a time– and voltage–dependent outward K+ current and a slow inward Ca2+ current, with a slight decrease of a fast inward Na+ current following halothane (1.0–4.0%) application; and that halothane has no effect on another K+ current, time–independent current.

本文言語英語
ページ(範囲)333-338
ページ数6
ジャーナルActa Anaesthesiologica Scandinavica
32
4
DOI
出版ステータス出版済み - 1988/05

ASJC Scopus 主題領域

  • 麻酔学および疼痛医療

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