Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring

Sarika Nunobiki, Ayano Yoshimoto, Makiko Ito, Sakura Yonoichi, Yukako Hara, Yuya Ishida, Rinako Morishita, Youhei Mantani, Toshifumi Yokoyama, Tetsushi Hirano, Yoshinori Ikenaka, Nobuhiko Hoshi*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Our previous reports showed that exposure to the neonicotinoid pesticide clothianidin (CLO) at a no-observed-adverse-effect-level (NOAEL) dose during fetal development and lactation in mice led to higher rates of maternal neglect and infanticide. Although the demonstrated association between decreased oxytocin secretion and decreased maternal parenting behavior implies a link to declining oxytocin levels, no evidence has yet emerged in CLO to clearly establish such an association. This study investigated the effects of CLO on maternal behavior and oxytocin in C57BL/6N mice exposed during pregnancy and lactation (F0 mothers) as well as in their adult female offspring (F1 mothers). The effects were assessed using nest building assays during pregnancy and pup retrieval assessment after delivery. The results showed a decrease in oxytocin secretion and a marked decrease in pup retrieval behavior among the F0 mothers in the CLO exposure group compared to those in the control group. Their offspring, the F1 mothers, showed significantly lower nest-building scores during pregnancy. In conclusion, this study is the first to examine the potential mechanisms by which CLO exposure in mothers at the NOAEL dose during pregnancy and lactation results in reduced plasma oxytocin levels, subsequently leading to a decline in maternal behaviors such as pup retrieval. Furthermore, these effects may impair maternal behaviors in the next generation, when the offspring mice become mothers.

本文言語英語
ページ(範囲)411-418
ページ数8
ジャーナルJournal of Veterinary Medical Science
87
4
DOI
出版ステータス出版済み - 2025

ASJC Scopus 主題領域

  • 獣医学一般

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