Effect of oxygen on the reaction of secondary amines with nitric oxide

Takashi Itoh; Yûji Matsuya; Hiromi Maeta; Michiko Miyazaki; Kazuhiro Nagata; Akio Ohsawa

doi:10.1248/cpb.47.133

Effect of oxygen on the reaction of secondary amines with nitric oxide

Takashi Itoh, Yûji Matsuya, Hiromi Maeta, Michiko Miyazaki, Kazuhiro Nagata, Akio Ohsawa^*

^*この論文の責任著者

薬品製造学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

10 被引用数 (Scopus)

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Secondary amines were allowed to react with nitric oxide in the presence of oxygen to afford N-nitrosamines in good yields. Detailed investigation revealed that the reaction proceeded by two pathways; the one involves the catalytic behavior of oxygen, and the other consumes a stoichiometrical amount of oxygen. Both pathways afforded the same nitroso adducts.

本文言語	英語
ページ（範囲）	133-135
ページ数	3
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	47
号	1
DOI	https://doi.org/10.1248/cpb.47.133
出版ステータス	出版済み - 1999/01

ASJC Scopus 主題領域

化学一般
創薬

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10.1248/cpb.47.133

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abstract = "Secondary amines were allowed to react with nitric oxide in the presence of oxygen to afford N-nitrosamines in good yields. Detailed investigation revealed that the reaction proceeded by two pathways; the one involves the catalytic behavior of oxygen, and the other consumes a stoichiometrical amount of oxygen. Both pathways afforded the same nitroso adducts.",

keywords = "Dinitrogen trioxide, N-nitrosamine, Nitric oxide, Nitrosation",

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AU - Itoh, Takashi

AU - Matsuya, Yûji

AU - Maeta, Hiromi

AU - Miyazaki, Michiko

AU - Nagata, Kazuhiro

AU - Ohsawa, Akio

PY - 1999/1

Y1 - 1999/1

N2 - Secondary amines were allowed to react with nitric oxide in the presence of oxygen to afford N-nitrosamines in good yields. Detailed investigation revealed that the reaction proceeded by two pathways; the one involves the catalytic behavior of oxygen, and the other consumes a stoichiometrical amount of oxygen. Both pathways afforded the same nitroso adducts.

AB - Secondary amines were allowed to react with nitric oxide in the presence of oxygen to afford N-nitrosamines in good yields. Detailed investigation revealed that the reaction proceeded by two pathways; the one involves the catalytic behavior of oxygen, and the other consumes a stoichiometrical amount of oxygen. Both pathways afforded the same nitroso adducts.

KW - Dinitrogen trioxide

KW - N-nitrosamine

KW - Nitric oxide

KW - Nitrosation

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M3 - 学術論文

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Effect of oxygen on the reaction of secondary amines with nitric oxide

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