TY - JOUR
T1 - Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage
T2 - a retrospective cohort study
AU - Kamidani, Ryo
AU - Miyake, Takahito
AU - Okada, Hideshi
AU - Yoshimura, Genki
AU - Kusuzawa, Keigo
AU - Miura, Tomotaka
AU - Shimaoka, Ryuichi
AU - Oiwa, Hideaki
AU - Yamaji, Fuminori
AU - Mizuno, Yosuke
AU - Yasuda, Ryu
AU - Kitagawa, Yuichiro
AU - Fukuta, Tetsuya
AU - Ishihara, Takuma
AU - Shiga, Tomomi
AU - Okamoto, Haruka
AU - Tachi, Masahito
AU - Shiba, Masato
AU - Kanda, Norihide
AU - Nachi, Sho
AU - Doi, Tomoaki
AU - Yoshida, Takahiro
AU - Yoshida, Shozo
AU - Morishige, Kenichiro
AU - Ogura, Shinji
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH referred to Gifu University Hospital between April 2013 and March 2020. We analyzed the effect of CRYO transfusion on fluid balance 24 h after the initial examination using a multivariable linear regression model adjusted for several confounding variables. To evaluate whether outcomes were modified by active bleeding, an interaction term of CRYO*active bleeding was incorporated into the multivariable model. We identified 157 women: 38 in the CRYO group (cases) and 119 in the control group. Fluid balance in the aforementioned period tended to decrease in the CRYO group compared with that in the control group (coefficient − 398.91; 95% CI − 1298.08 to + 500.26; p = 0.382). Active bleeding on contrast-enhanced computed tomography affected the relationship between CRYO transfusion and fluid balance (p = 0.016). Other outcomes, except for the overall transfusion requirement, were not significantly different; however, the interaction effect of active bleeding was significant (p = 0.016). CRYO transfusion may decrease the fluid balance in the first 24 h in PPH patients, especially in those without active bleeding.
AB - To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH referred to Gifu University Hospital between April 2013 and March 2020. We analyzed the effect of CRYO transfusion on fluid balance 24 h after the initial examination using a multivariable linear regression model adjusted for several confounding variables. To evaluate whether outcomes were modified by active bleeding, an interaction term of CRYO*active bleeding was incorporated into the multivariable model. We identified 157 women: 38 in the CRYO group (cases) and 119 in the control group. Fluid balance in the aforementioned period tended to decrease in the CRYO group compared with that in the control group (coefficient − 398.91; 95% CI − 1298.08 to + 500.26; p = 0.382). Active bleeding on contrast-enhanced computed tomography affected the relationship between CRYO transfusion and fluid balance (p = 0.016). Other outcomes, except for the overall transfusion requirement, were not significantly different; however, the interaction effect of active bleeding was significant (p = 0.016). CRYO transfusion may decrease the fluid balance in the first 24 h in PPH patients, especially in those without active bleeding.
UR - http://www.scopus.com/inward/record.url?scp=85115303980&partnerID=8YFLogxK
U2 - 10.1038/s41598-021-97954-5
DO - 10.1038/s41598-021-97954-5
M3 - 学術論文
C2 - 34531466
AN - SCOPUS:85115303980
SN - 2045-2322
VL - 11
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 18458
ER -