Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: A relationship between telomeres and nitric oxide

Keyphrases

• Age-matched 10%
• Aged Rats 10%
• Anti-senescence 10%
• Aortic Endothelium 10%
• Cardiovascular Risk 10%
• Cellular Senescence 10%
• Diabetes 10%
• Dose Effect 100%
• Endothelial Function 10%
• Endothelial Nitric Oxide 10%
• Endothelial Nitric Oxide Synthase (eNOS) 10%
• Endothelial Senescence 100%
• High Concentration 10%
• High Glucose 60%
• Human Endothelial Cells 10%
• Insulin 100%
• Insulin Therapy 10%
• Insulin-treated 10%
• MiRNA Target 10%
• Modulatory Effects 100%
• Nitric Oxide 100%
• Physiological Concentrations 20%
• Plasma Concentration 10%
• Postprandial Hyperglycemia 10%
• Reactive Oxygen Species 10%
• Regulatory Effect 10%
• Regulatory Role 10%
• Replicative Senescence 20%
• Senescence Marker Protein 30 (SMP30) 10%
• Senescence Markers 20%
• Senescence-associated 10%
• Senescent Cells 10%
• Small Interfering RNA (siRNA) 10%
• Streptozotocin-induced Diabetes 10%
• Stress-induced Premature Senescence 10%
• Telomerase Activity 10%
• Telomere 100%
• Telomere Length 10%
• Vascular Cell Adhesion molecule-1 (VCAM-1) 10%
• β-Galactosidase (β-Gal) 10%

Agricultural and Biological Sciences

• Blood Plasma 50%
• Cardiovascular System 50%
• Cellular Senescence 50%
• Endothelial Cells 50%
• Endothelial Nitric Oxide Synthase 50%
• Galactosidase 50%
• Hyperglycemia 50%
• Small Interfering RNA 50%
• Streptozotocin 50%
• Telomerase 50%
• Telomere 100%
• VCAM-1 50%

Biochemistry, Genetics and Molecular Biology

• Blood Level 33%
• Galactosidase 33%
• Hyperglycemia 33%
• Insulin 33%
• Nitric Oxide 100%
• Nitric Oxide Synthase 33%
• P53 33%
• Small Interfering RNA 33%
• Streptozotocin 33%
• Telomerase 33%
• Telomere 100%
• Telomere Length 33%
• VCAM-1 33%