TY - JOUR
T1 - Does edaravone (MCI-186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
AU - Dohi, Kenji
AU - Satoh, Kazue
AU - Nakamachi, Tomoya
AU - Yofu, Sachiko
AU - Hiratsuka, Keisuke
AU - Nakamura, Shunsuke
AU - Ohtaki, Hirokazu
AU - Yoshikawa, Toshikazu
AU - Shioda, Seiji
AU - Aruga, Tohru
PY - 2007/2
Y1 - 2007/2
N2 - Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.
AB - Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.
UR - http://www.scopus.com/inward/record.url?scp=33846217424&partnerID=8YFLogxK
U2 - 10.1089/ars.2007.9.281
DO - 10.1089/ars.2007.9.281
M3 - 簡易調査
C2 - 17115943
AN - SCOPUS:33846217424
SN - 1523-0864
VL - 9
SP - 281
EP - 287
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
IS - 2
ER -