TY - JOUR
T1 - Disconnected pancreatic duct syndrome
T2 - diagnostic and therapeutic challenges and future directions
AU - Takenaka, Mamoru
AU - Saito, Tomotaka
AU - Hamada, Tsuyoshi
AU - Omoto, Shunsuke
AU - Shiomi, Hideyuki
AU - Iwashita, Takuji
AU - Masuda, Atsuhiro
AU - Matsubara, Saburo
AU - Maruta, Akinori
AU - Iwata, Keisuke
AU - Mukai, Tsuyoshi
AU - Isayama, Hiroyuki
AU - Yasuda, Ichiro
AU - Nakai, Yousuke
N1 - Publisher Copyright:
© 2024 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2024
Y1 - 2024
N2 - Introduction: Disconnected pancreatic duct syndrome (DPDS) is a pathological condition that causes various symptoms due to the continuous secretion of pancreatic enzymes from the pancreas upstream, which has been separated due to disconnection of the pancreatic duct (DPD) for various reasons. Acute necrotizing pancreatitis includes a certain probability of DPDS appearance, which makes it necessary to provide various treatments for DPDS. Furthermore, DPDS can impact long-term results, such as recurrence and impaired pancreatic function. Although the development of various modalities has contributed to diagnosis and treatment, especially less invasive endoscopic therapy, DPDS is often overlooked, and the diagnosis can be delayed due to the lack of consensus on its definition and classification. This review summarizes the current knowledge and challenges of DPDS and discusses the optimal strategy for its diagnosis and treatment, as well as future perspectives. Areas covered: Given the lack of established definition, diagnosis, and treatment of DPDS, we conducted a thorough review of the existing literature. Expert opinion: It is emphasized that a standardized definition and classification of DPDS is essential for designing and conducting clinical studies to address current unmet needs in managing patients with DPDS.
AB - Introduction: Disconnected pancreatic duct syndrome (DPDS) is a pathological condition that causes various symptoms due to the continuous secretion of pancreatic enzymes from the pancreas upstream, which has been separated due to disconnection of the pancreatic duct (DPD) for various reasons. Acute necrotizing pancreatitis includes a certain probability of DPDS appearance, which makes it necessary to provide various treatments for DPDS. Furthermore, DPDS can impact long-term results, such as recurrence and impaired pancreatic function. Although the development of various modalities has contributed to diagnosis and treatment, especially less invasive endoscopic therapy, DPDS is often overlooked, and the diagnosis can be delayed due to the lack of consensus on its definition and classification. This review summarizes the current knowledge and challenges of DPDS and discusses the optimal strategy for its diagnosis and treatment, as well as future perspectives. Areas covered: Given the lack of established definition, diagnosis, and treatment of DPDS, we conducted a thorough review of the existing literature. Expert opinion: It is emphasized that a standardized definition and classification of DPDS is essential for designing and conducting clinical studies to address current unmet needs in managing patients with DPDS.
KW - acute-necrotizing pancreatitis (ANP)
KW - Disconnected pancreatic duct syndrome (DPDS)
KW - EUS-guided pancreatic duct drainage (EUS-PDD)
KW - EUS-guided peripancreatic fluid drainage (EUS-PFD)
KW - walled-off necrosis (WON)
UR - http://www.scopus.com/inward/record.url?scp=85207508123&partnerID=8YFLogxK
U2 - 10.1080/17474124.2024.2419056
DO - 10.1080/17474124.2024.2419056
M3 - 総説
C2 - 39420546
AN - SCOPUS:85207508123
SN - 1747-4124
VL - 18
SP - 631
EP - 645
JO - Expert Review of Gastroenterology and Hepatology
JF - Expert Review of Gastroenterology and Hepatology
IS - 10
ER -