TY - JOUR
T1 - Dietary docosahexaenoic acid but not eicosapentaenoic acid suppresses lipopolysaccharide-induced interleukin-1β mRNA induction in mouse spleen leukocytes
AU - Watanabe, S.
AU - Katagiri, K.
AU - Onozaki, K.
AU - Hata, N.
AU - Misawa, Y.
AU - Hamazaki, T.
AU - Okuyama, O.
N1 - Funding Information:
This work was supported in part by Special Coordination Funds for Promoting Science and Technology of the Science and Technology Agency of the Japan Government and by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.
PY - 2000/3
Y1 - 2000/3
N2 - Mice were fed a diet supplemented either with beef tallow (BT), BT plus ethyl eicosapentaenoate (EPA) or BT plus ethyl docosahexaenoate (DHA) for 9 weeks. EPA and DHA supplementation increased the content of the respective fatty acid in spleen leukocyte lipids, which was associated with the reduction in the arachidonate content. IL-1β mRNA induction upon lipopolysaccharide (LPS) stimulation in spleen leukocytes in the DHA diet group was significantly lower than in the BT diet group, but the EPA diet was without any significant effect. The amount of prostaglandin E2 (PGE2) released from LPS-stimulated spleen leukocytes was significantly lower in both the EPA and DHA groups than in the BT group. Thus, dietary EPA and DHA inhibited arachidonate metabolism similarly but had different effects on IL-1β mRNA induction in mouse spleen leukocytes. (C) 2000 Harcourt Publishers Ltd.
AB - Mice were fed a diet supplemented either with beef tallow (BT), BT plus ethyl eicosapentaenoate (EPA) or BT plus ethyl docosahexaenoate (DHA) for 9 weeks. EPA and DHA supplementation increased the content of the respective fatty acid in spleen leukocyte lipids, which was associated with the reduction in the arachidonate content. IL-1β mRNA induction upon lipopolysaccharide (LPS) stimulation in spleen leukocytes in the DHA diet group was significantly lower than in the BT diet group, but the EPA diet was without any significant effect. The amount of prostaglandin E2 (PGE2) released from LPS-stimulated spleen leukocytes was significantly lower in both the EPA and DHA groups than in the BT group. Thus, dietary EPA and DHA inhibited arachidonate metabolism similarly but had different effects on IL-1β mRNA induction in mouse spleen leukocytes. (C) 2000 Harcourt Publishers Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0034127019&partnerID=8YFLogxK
U2 - 10.1054/plef.2000.0134
DO - 10.1054/plef.2000.0134
M3 - 学術論文
C2 - 10841036
AN - SCOPUS:0034127019
SN - 0952-3278
VL - 62
SP - 147
EP - 152
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 3
ER -