TY - JOUR
T1 - Diabetic neuropathies in brain are induced by deficiency of BDNF
AU - Nitta, A.
AU - Murai, R.
AU - Suzuki, N.
AU - Ito, H.
AU - Nomoto, H.
AU - Katoh, G.
AU - Furukawa, Y.
AU - Furukawa, S.
N1 - Funding Information:
The study was supported in part by a grant from the Smoking Research Foundation.
PY - 2002/9
Y1 - 2002/9
N2 - Diabetes is known to be one of the risk factors for dementia; however, neuropathic changes in the brain of patients with the disease have not been completely revealed. So in the present study, we investigated the brain function of rats with diabetes induced by streptozotocin (STZ), one of the most commonly used animal models for diabetes. In the diabetic rats, immediately working memory performance was impaired in the Y-maze task and neuronal cytoskeleton proteins such as calbindin, synaptophysin, and syntaxin were reduced. Furthermore, morphological observation by Golgi staining showed a decrease in the number of basal dendrites and abnormality of spine structure. Next, we measured the content of brain-derived neurotrophic factor (BDNF) in the diabetic brain, because BDNF is one of the essential proteins for the maintenance of neuronal functions including synapse function and neuronal transmissions. In the diabetic brains, both protein and mRNA levels of BDNF were severely reduced. These results suggest that, in diabetes, synapse dysfunction is, at least in part, caused by a failure of BDNF synthesis in the brain.
AB - Diabetes is known to be one of the risk factors for dementia; however, neuropathic changes in the brain of patients with the disease have not been completely revealed. So in the present study, we investigated the brain function of rats with diabetes induced by streptozotocin (STZ), one of the most commonly used animal models for diabetes. In the diabetic rats, immediately working memory performance was impaired in the Y-maze task and neuronal cytoskeleton proteins such as calbindin, synaptophysin, and syntaxin were reduced. Furthermore, morphological observation by Golgi staining showed a decrease in the number of basal dendrites and abnormality of spine structure. Next, we measured the content of brain-derived neurotrophic factor (BDNF) in the diabetic brain, because BDNF is one of the essential proteins for the maintenance of neuronal functions including synapse function and neuronal transmissions. In the diabetic brains, both protein and mRNA levels of BDNF were severely reduced. These results suggest that, in diabetes, synapse dysfunction is, at least in part, caused by a failure of BDNF synthesis in the brain.
KW - Brain-derived neurotrophic factor
KW - Diabetes
KW - Learning memory
KW - Rats
KW - Y-maze task
UR - http://www.scopus.com/inward/record.url?scp=0036715390&partnerID=8YFLogxK
U2 - 10.1016/S0892-0362(02)00220-9
DO - 10.1016/S0892-0362(02)00220-9
M3 - 総説
C2 - 12200200
AN - SCOPUS:0036715390
SN - 0892-0362
VL - 24
SP - 695
EP - 701
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
IS - 5
ER -
