Design and screening of gallic acid derivatives as inhibitors of malarial dihydrofolate reductase by in silico docking

Keyphrases

• Gallic Acid Derivatives 100%
• Methylenetetrahydrofolate Reductase (MTHFR) 100%
• In Silico Docking 100%
• 3D Structure 40%
• Octyl Gallate 40%
• Gallic Acid 40%
• MOE Software 40%
• High Prevalence 20%
• Aromatic Ring 20%
• Inhibitory Activity 20%
• Infectious Diseases 20%
• In Silico Methods 20%
• Threonine 20%
• Malaria 20%
• Amino Acid Analysis 20%
• Antimalarial Drugs 20%
• Methoxyl Group 20%
• Compound II 20%
• Tropics 20%
• Strong Interaction 20%
• Plasmodium Parasite 20%
• Energy Minimization 20%
• Antimalaria 20%
• Docking Technique 20%
• Energy Optimization 20%
• Hydroxyl Group 20%
• Open Chain 20%
• Allylic Ester 20%
• Subtropics 20%
• Geometry Optimization 20%
• Carboxyl Group 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Gallic Acid Derivative 100%
• Dihydrofolate Reductase 100%
• Gallic Acid 80%
• Disease 20%
• Amino Acid 20%
• Prevalence 20%
• Receptor 20%
• Plasmodium 20%
• Hydroxyl Group 20%
• Allyl 20%
• Carboxyl Group 20%
• Threonine 20%
• Infection 20%
• Antimalarial Agent 20%