Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

Atsumi Nitta; Yoshiko Furukawa; Kyozo Hayashi; Masayuki Hiramatsu; Tsutomu Kameyama; Takaaki Hasegawa; Toshitaka Nabeshima

doi:10.1016/0304-3940(92)90738-S

Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

Atsumi Nitta, Yoshiko Furukawa, Kyozo Hayashi, Masayuki Hiramatsu, Tsutomu Kameyama, Takaaki Hasegawa, Toshitaka Nabeshima^*

^*この論文の責任著者

薬物治療学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

55 被引用数 (Scopus)

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Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

本文言語	英語
ページ（範囲）	152-156
ページ数	5
ジャーナル	Neuroscience Letters
巻	144
号	1-2
DOI	https://doi.org/10.1016/0304-3940(92)90738-S
出版ステータス	出版済み - 1992/09/14

ASJC Scopus 主題領域

神経科学一般

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10.1016/0304-3940(92)90738-S

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@article{140695ed6b4c43fab221af2b1494a3d3,

title = "Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain",

abstract = "Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.",

keywords = "6-Hydroxydopamine, Cortex, Dopaminergic denervation, Hippocampus, Nerve growth factor, Rat",

author = "Atsumi Nitta and Yoshiko Furukawa and Kyozo Hayashi and Masayuki Hiramatsu and Tsutomu Kameyama and Takaaki Hasegawa and Toshitaka Nabeshima",

note = "Funding Information: This study was supported, in part, by a grant from the Sandoz Foundation for Gerontological Research and by the Mrs. Kimi Tokuda Memorial Foundation.",

year = "1992",

month = sep,

day = "14",

doi = "10.1016/0304-3940(92)90738-S",

language = "英語",

volume = "144",

pages = "152--156",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

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TY - JOUR

T1 - Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

AU - Nitta, Atsumi

AU - Furukawa, Yoshiko

AU - Hayashi, Kyozo

AU - Hiramatsu, Masayuki

AU - Kameyama, Tsutomu

AU - Hasegawa, Takaaki

AU - Nabeshima, Toshitaka

N1 - Funding Information: This study was supported, in part, by a grant from the Sandoz Foundation for Gerontological Research and by the Mrs. Kimi Tokuda Memorial Foundation.

PY - 1992/9/14

Y1 - 1992/9/14

N2 - Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

AB - Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

KW - 6-Hydroxydopamine

KW - Cortex

KW - Dopaminergic denervation

KW - Hippocampus

KW - Nerve growth factor

KW - Rat

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U2 - 10.1016/0304-3940(92)90738-S

DO - 10.1016/0304-3940(92)90738-S

M3 - 学術論文

C2 - 1436695

AN - SCOPUS:0026666242

SN - 0304-3940

VL - 144

SP - 152

EP - 156

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

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