Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis

Juan Wang; Ze Kun Zhang; Fang Fang Jiang; Bo Wen Qi; Ning Ding; Saw Yu Yu Hnin; Xiao Liu; Jun Li; Xiao Hui Wang; Peng Fei Tu; Ikuro Abe; Hiroyuki Morita; She Po Shi

doi:10.1021/ACS.ORGLETT.0C03339

Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis

Juan Wang, Ze Kun Zhang, Fang Fang Jiang, Bo Wen Qi, Ning Ding, Saw Yu Yu Hnin, Xiao Liu, Jun Li, Xiao Hui Wang, Peng Fei Tu^*, Ikuro Abe^*, Hiroyuki Morita^*, She Po Shi^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

22 被引用数 (Scopus)

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Pelletierine, a proposed building block of Lycopodium alkaloids (LAs), was demonstrated to be synthesized via the non-enzymatic Mannich-like condensation of Δ¹-piperideine and 3-oxoglutaric acid produced by two new type III PKSs (HsPKS4 and PcPKS1) characterized from Huperzia serrata and Phlegmariurus cryptomerianus, respectively. The findings provide new insights for further understanding the biosynthesis of LAs such as huperzine A.(Figure Presented).

本文言語	英語
ページ（範囲）	8725-8729
ページ数	5
ジャーナル	Organic Letters
巻	22
号	21
DOI	https://doi.org/10.1021/ACS.ORGLETT.0C03339
出版ステータス	出版済み - 2020/11/06

ASJC Scopus 主題領域

生化学
物理化学および理論化学
有機化学

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10.1021/ACS.ORGLETT.0C03339

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title = "Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis",

abstract = "Pelletierine, a proposed building block of Lycopodium alkaloids (LAs), was demonstrated to be synthesized via the non-enzymatic Mannich-like condensation of Δ1-piperideine and 3-oxoglutaric acid produced by two new type III PKSs (HsPKS4 and PcPKS1) characterized from Huperzia serrata and Phlegmariurus cryptomerianus, respectively. The findings provide new insights for further understanding the biosynthesis of LAs such as huperzine A.(Figure Presented).",

author = "Juan Wang and Zhang, {Ze Kun} and Jiang, {Fang Fang} and Qi, {Bo Wen} and Ning Ding and Hnin, {Saw Yu Yu} and Xiao Liu and Jun Li and Wang, {Xiao Hui} and Tu, {Peng Fei} and Ikuro Abe and Hiroyuki Morita and Shi, {She Po}",

note = "Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",

year = "2020",

month = nov,

day = "6",

doi = "10.1021/ACS.ORGLETT.0C03339",

language = "英語",

volume = "22",

pages = "8725--8729",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis

AU - Wang, Juan

AU - Zhang, Ze Kun

AU - Jiang, Fang Fang

AU - Qi, Bo Wen

AU - Ding, Ning

AU - Hnin, Saw Yu Yu

AU - Liu, Xiao

AU - Li, Jun

AU - Wang, Xiao Hui

AU - Tu, Peng Fei

AU - Abe, Ikuro

AU - Morita, Hiroyuki

AU - Shi, She Po

PY - 2020/11/6

Y1 - 2020/11/6

N2 - Pelletierine, a proposed building block of Lycopodium alkaloids (LAs), was demonstrated to be synthesized via the non-enzymatic Mannich-like condensation of Δ1-piperideine and 3-oxoglutaric acid produced by two new type III PKSs (HsPKS4 and PcPKS1) characterized from Huperzia serrata and Phlegmariurus cryptomerianus, respectively. The findings provide new insights for further understanding the biosynthesis of LAs such as huperzine A.(Figure Presented).

AB - Pelletierine, a proposed building block of Lycopodium alkaloids (LAs), was demonstrated to be synthesized via the non-enzymatic Mannich-like condensation of Δ1-piperideine and 3-oxoglutaric acid produced by two new type III PKSs (HsPKS4 and PcPKS1) characterized from Huperzia serrata and Phlegmariurus cryptomerianus, respectively. The findings provide new insights for further understanding the biosynthesis of LAs such as huperzine A.(Figure Presented).

UR - http://www.scopus.com/inward/record.url?scp=85095829347&partnerID=8YFLogxK

U2 - 10.1021/ACS.ORGLETT.0C03339

DO - 10.1021/ACS.ORGLETT.0C03339

M3 - 学術論文

C2 - 33104367

AN - SCOPUS:85095829347

SN - 1523-7060

VL - 22

SP - 8725

EP - 8729

JO - Organic Letters

JF - Organic Letters

IS - 21

ER -

Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis

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