TY - JOUR
T1 - Daurichromenic acid-producing oxidocyclase in the young leaves of Rhododendron dauricum
AU - Taura, Futoshi
AU - Iijima, Miu
AU - Lee, Jung Bum
AU - Hashimoto, Toshihiro
AU - Asakawa, Yoshinori
AU - Kurosaki, Fumiya
N1 - Publisher Copyright:
© 2014, Natural Product Incorporation. All rights reserved.
PY - 2014/9
Y1 - 2014/9
N2 - Rhododendron dauricum L., a flowering tree popular in Hokkaido, produces daurichromenic acid (DCA), a terpenophenol with a potent anti-HIV activity. The DCA-producing enzyme, named DCA synthase, could be detected in the soluble protein fraction prepared from the young leaves of R. dauricum. DCA synthase catalyzed oxidocyclization of the farnesyl group of grifolic acid to form (+)-DCA as the major reaction product. The DCA synthase reaction proceeds without the need for any cofactors and coenzymes except for molecular oxygen. Interestingly, these catalytic properties of DCA synthase are quite similar to those reported for cannabinoid synthases in the marijuana plant Cannabis sativa L.
AB - Rhododendron dauricum L., a flowering tree popular in Hokkaido, produces daurichromenic acid (DCA), a terpenophenol with a potent anti-HIV activity. The DCA-producing enzyme, named DCA synthase, could be detected in the soluble protein fraction prepared from the young leaves of R. dauricum. DCA synthase catalyzed oxidocyclization of the farnesyl group of grifolic acid to form (+)-DCA as the major reaction product. The DCA synthase reaction proceeds without the need for any cofactors and coenzymes except for molecular oxygen. Interestingly, these catalytic properties of DCA synthase are quite similar to those reported for cannabinoid synthases in the marijuana plant Cannabis sativa L.
KW - Anti-HIV natural product
KW - Biosynthesis
KW - Daurichromenic acid
KW - Rhododendron dauricum L.
UR - http://www.scopus.com/inward/record.url?scp=84907522210&partnerID=8YFLogxK
U2 - 10.1177/1934578x1400900928
DO - 10.1177/1934578x1400900928
M3 - 学術論文
C2 - 25918805
AN - SCOPUS:84907522210
SN - 1934-578X
VL - 9
SP - 1329
EP - 1332
JO - Natural Product Communications
JF - Natural Product Communications
IS - 9
ER -