Cytotoxic dimeric sesquiterpenoids from Curcuma parviflora: Isolation of three new parviflorenes and absolute stereochemistry of parviflorenes A, B, D, F, and G

Kazufumi Toume; Masaaki Sato; Takashi Koyano; Thaworn Kowithayakorn; Takao Yamori; Masami Ishibashi

doi:10.1016/j.tet.2005.05.016

Cytotoxic dimeric sesquiterpenoids from Curcuma parviflora: Isolation of three new parviflorenes and absolute stereochemistry of parviflorenes A, B, D, F, and G

Kazufumi Toume, Masaaki Sato, Takashi Koyano, Thaworn Kowithayakorn, Takao Yamori, Masami Ishibashi^*

^*この論文の責任著者

和漢医薬学総合研究所薬用資源管理部門

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

17 被引用数 (Scopus)

抄録

Three novel dimeric sesquiterpenoids, named parviflorenes G-I (1-3), have been isolated from Curcuma parviflora (Zingiberaceae), and their structures were elucidated by means of spectroscopic studies. Absolute stereochemistry of parviflorene G (1) as well as previously isolated related compounds, parviflorenes A (4), B (5), D (6), and F (7), was revealed by CD spectral data and chemical means. Parviflorenes G (1) and I (3) were cytotoxic against HeLa cells, while parviflorenes A (4) and F (7) were cytotoxic against all tested tumor cell lines in the human cancer cell line panel assay.

本文言語	英語
ページ（範囲）	6700-6706
ページ数	7
ジャーナル	Tetrahedron
巻	61
号	28
DOI	https://doi.org/10.1016/j.tet.2005.05.016
出版ステータス	出版済み - 2005/07/11

ASJC Scopus 主題領域

生化学
創薬
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1016/j.tet.2005.05.016

フィンガープリント

「Cytotoxic dimeric sesquiterpenoids from Curcuma parviflora: Isolation of three new parviflorenes and absolute stereochemistry of parviflorenes A, B, D, F, and G」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

@article{750f6cb686584d959a29755c58433a00,

title = "Cytotoxic dimeric sesquiterpenoids from Curcuma parviflora: Isolation of three new parviflorenes and absolute stereochemistry of parviflorenes A, B, D, F, and G",

abstract = "Three novel dimeric sesquiterpenoids, named parviflorenes G-I (1-3), have been isolated from Curcuma parviflora (Zingiberaceae), and their structures were elucidated by means of spectroscopic studies. Absolute stereochemistry of parviflorene G (1) as well as previously isolated related compounds, parviflorenes A (4), B (5), D (6), and F (7), was revealed by CD spectral data and chemical means. Parviflorenes G (1) and I (3) were cytotoxic against HeLa cells, while parviflorenes A (4) and F (7) were cytotoxic against all tested tumor cell lines in the human cancer cell line panel assay.",

keywords = "Absolute stereochemistry, Curcuma parviflora, Cytotoxicity, Dimeric sesquiterpene, Zingiberaceae",

author = "Kazufumi Toume and Masaaki Sato and Takashi Koyano and Thaworn Kowithayakorn and Takao Yamori and Masami Ishibashi",

note = "Funding Information: This work was partly supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and by a Grant-in-Aid from the Keimeikai Foundation.",

year = "2005",

month = jul,

day = "11",

doi = "10.1016/j.tet.2005.05.016",

language = "英語",

volume = "61",

pages = "6700--6706",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd.",

number = "28",

}

TY - JOUR

T1 - Cytotoxic dimeric sesquiterpenoids from Curcuma parviflora

T2 - Isolation of three new parviflorenes and absolute stereochemistry of parviflorenes A, B, D, F, and G

AU - Toume, Kazufumi

AU - Sato, Masaaki

AU - Koyano, Takashi

AU - Kowithayakorn, Thaworn

AU - Yamori, Takao

AU - Ishibashi, Masami

N1 - Funding Information: This work was partly supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and by a Grant-in-Aid from the Keimeikai Foundation.

PY - 2005/7/11

Y1 - 2005/7/11

N2 - Three novel dimeric sesquiterpenoids, named parviflorenes G-I (1-3), have been isolated from Curcuma parviflora (Zingiberaceae), and their structures were elucidated by means of spectroscopic studies. Absolute stereochemistry of parviflorene G (1) as well as previously isolated related compounds, parviflorenes A (4), B (5), D (6), and F (7), was revealed by CD spectral data and chemical means. Parviflorenes G (1) and I (3) were cytotoxic against HeLa cells, while parviflorenes A (4) and F (7) were cytotoxic against all tested tumor cell lines in the human cancer cell line panel assay.

AB - Three novel dimeric sesquiterpenoids, named parviflorenes G-I (1-3), have been isolated from Curcuma parviflora (Zingiberaceae), and their structures were elucidated by means of spectroscopic studies. Absolute stereochemistry of parviflorene G (1) as well as previously isolated related compounds, parviflorenes A (4), B (5), D (6), and F (7), was revealed by CD spectral data and chemical means. Parviflorenes G (1) and I (3) were cytotoxic against HeLa cells, while parviflorenes A (4) and F (7) were cytotoxic against all tested tumor cell lines in the human cancer cell line panel assay.

KW - Absolute stereochemistry

KW - Curcuma parviflora

KW - Cytotoxicity

KW - Dimeric sesquiterpene

KW - Zingiberaceae

UR - http://www.scopus.com/inward/record.url?scp=20444466851&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2005.05.016

DO - 10.1016/j.tet.2005.05.016

M3 - 学術論文

AN - SCOPUS:20444466851

SN - 0040-4020

VL - 61

SP - 6700

EP - 6706

JO - Tetrahedron

JF - Tetrahedron

IS - 28

ER -