Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis

Yasuhiro Tezuka; Kouhei Morikawa; Feng Li; Lidyawati Auw; Suresh Awale; Takahiro Nobukawa; Shigetoshi Kadota

doi:10.1021/np100665j

Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis

Yasuhiro Tezuka^*, Kouhei Morikawa, Feng Li, Lidyawati Auw, Suresh Awale, Takahiro Nobukawa, Shigetoshi Kadota

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

27 被引用数 (Scopus)

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From the aqueous extract of the wood of Taxus yunnanensis, which showed cytochrome P450 3A4 (CYP3A4) inhibition, a new isoflavan [(3S,4R)-4'-hydroxy-6, 3'-dimethoxyisoflavan-4-ol (1)], a new degraded lignan [2,3-bis(hydroxymethyl)- 7-hydroxy-6-methoxy-1-tetralone (2)], and a new lignan [(7R)-7- hydroxytaxiresinol (3)] were isolated, together with nine known lignans. Among the isolates obtained, R-conidendrin (12) showed strong CYP3A4 inhibition with an IC₅₀ value of 0.2 μM.

本文言語	英語
ページ（範囲）	102-105
ページ数	4
ジャーナル	Journal of Natural Products
巻	74
号	1
DOI	https://doi.org/10.1021/np100665j
出版ステータス	出版済み - 2011/01/28

ASJC Scopus 主題領域

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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10.1021/np100665j

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title = "Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis",

abstract = "From the aqueous extract of the wood of Taxus yunnanensis, which showed cytochrome P450 3A4 (CYP3A4) inhibition, a new isoflavan [(3S,4R)-4'-hydroxy-6, 3'-dimethoxyisoflavan-4-ol (1)], a new degraded lignan [2,3-bis(hydroxymethyl)- 7-hydroxy-6-methoxy-1-tetralone (2)], and a new lignan [(7R)-7- hydroxytaxiresinol (3)] were isolated, together with nine known lignans. Among the isolates obtained, R-conidendrin (12) showed strong CYP3A4 inhibition with an IC50 value of 0.2 μM.",

author = "Yasuhiro Tezuka and Kouhei Morikawa and Feng Li and Lidyawati Auw and Suresh Awale and Takahiro Nobukawa and Shigetoshi Kadota",

year = "2011",

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doi = "10.1021/np100665j",

language = "英語",

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T1 - Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis

AU - Tezuka, Yasuhiro

AU - Morikawa, Kouhei

AU - Li, Feng

AU - Auw, Lidyawati

AU - Awale, Suresh

AU - Nobukawa, Takahiro

AU - Kadota, Shigetoshi

PY - 2011/1/28

Y1 - 2011/1/28

N2 - From the aqueous extract of the wood of Taxus yunnanensis, which showed cytochrome P450 3A4 (CYP3A4) inhibition, a new isoflavan [(3S,4R)-4'-hydroxy-6, 3'-dimethoxyisoflavan-4-ol (1)], a new degraded lignan [2,3-bis(hydroxymethyl)- 7-hydroxy-6-methoxy-1-tetralone (2)], and a new lignan [(7R)-7- hydroxytaxiresinol (3)] were isolated, together with nine known lignans. Among the isolates obtained, R-conidendrin (12) showed strong CYP3A4 inhibition with an IC50 value of 0.2 μM.

AB - From the aqueous extract of the wood of Taxus yunnanensis, which showed cytochrome P450 3A4 (CYP3A4) inhibition, a new isoflavan [(3S,4R)-4'-hydroxy-6, 3'-dimethoxyisoflavan-4-ol (1)], a new degraded lignan [2,3-bis(hydroxymethyl)- 7-hydroxy-6-methoxy-1-tetralone (2)], and a new lignan [(7R)-7- hydroxytaxiresinol (3)] were isolated, together with nine known lignans. Among the isolates obtained, R-conidendrin (12) showed strong CYP3A4 inhibition with an IC50 value of 0.2 μM.

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M3 - 学術論文

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SN - 0163-3864

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Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis

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