Correlation Between Modified Low Density lipoprotein and Carotid Intima-medial Thickness in Climacteric Type 2 diabetics

We studied the relationship between the degree of intima-medial thickness (IMT) of carotid arteries, antibody against glycated and oxidized low density lipoprotein (Ab-glcLDL or Ab-oxLDL) and other risk factors for atherosclerosis and microangiopathy in patients with type 2 diabetes, 43 climacteric patients were compared to 20 control subjects. As an index of atherosclerosis, we measured the average thickness of 6 portions of the carotid artery wall. Ab-glcLDL and Ab-oxLDL were evaluated by ELISA. Mean IMT, HbA1C, total cholesterol, triglyceride, LDL-cholesterol, apolipoprotein B, lipoprotein (a), Ab-glcLDL, urinary albumin excretion rate (AER), and systolic blood pressure (SBP) were significantly higher in diabetics than those in controls. Logistic regression analysis indicated that glycemic controls and duration of diabetes contributed to the degree of IMT in diabetics with retinopathy. AER was a significantly related to SBP and BMI in diabetics. Ab-oxLDL was lower in diabetics than in controls. Although no evidence of a concurrent increase in Ab-glcLDL and Ab-oxLDL was found, we assume that hyperglycemia accerelated changes in LDL and contributed to macro- and microangiopathy in type 2 diabetes.