TY - JOUR
T1 - Continuous flow system with a polymer-supported dirhodium(II) catalyst
T2 - Application to enantioselective carbonyl ylide cycloaddition reactions
AU - Takeda, Koji
AU - Oohara, Tadashi
AU - Shimada, Naoyuki
AU - Nambu, Hisanori
AU - Hashimoto, Shunichi
PY - 2011/12/9
Y1 - 2011/12/9
N2 - The immobilization of [Rh 2(S-PTTL)(S-TCPTTL) 3] (PTTL = N-phthaloyl-tert-leucinate, TCPTTL=N-tetrachlorophthaloyl-tert-leucinate) has been accomplished by copolymerization of the Rh II-complex-containing monomer with 2-(trifluoromethyl)styrene and a flexible cross-linker. The immobilized catalyst promoted intermolecular carbonyl ylide cycloaddition reactions in CF 3C 6H 5 under continuous flow conditions, where high yields as well as high levels of enantioselectivity and turnover number were achieved.
AB - The immobilization of [Rh 2(S-PTTL)(S-TCPTTL) 3] (PTTL = N-phthaloyl-tert-leucinate, TCPTTL=N-tetrachlorophthaloyl-tert-leucinate) has been accomplished by copolymerization of the Rh II-complex-containing monomer with 2-(trifluoromethyl)styrene and a flexible cross-linker. The immobilized catalyst promoted intermolecular carbonyl ylide cycloaddition reactions in CF 3C 6H 5 under continuous flow conditions, where high yields as well as high levels of enantioselectivity and turnover number were achieved.
KW - asymmetric catalysis
KW - continuous flow system
KW - heterogeneous catalysis
KW - immobilization
KW - rhodium
UR - http://www.scopus.com/inward/record.url?scp=82955235121&partnerID=8YFLogxK
U2 - 10.1002/chem.201102733
DO - 10.1002/chem.201102733
M3 - 学術論文
C2 - 22095784
AN - SCOPUS:82955235121
SN - 0947-6539
VL - 17
SP - 13992
EP - 13998
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 50
ER -