Constituents from the rhizomes of Curcuma comosa and their Wnt signal inhibitory activities

Rolly G. Fuentes; Kazufumi Toume; Midori A. Arai; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi

doi:10.3987/COM-13-S(S)49

Constituents from the rhizomes of Curcuma comosa and their Wnt signal inhibitory activities

Rolly G. Fuentes, Kazufumi Toume, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi^*

^*この論文の責任著者

和漢医薬学総合研究所薬用資源管理部門

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

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Activity-guided fractionation of the Curcuma comosa rhizome MeOH extract that inhibited Wnt signal activity led to the characterization of two new diarylheptanoids (1 and 2) together with six known diarylheptanoids (3-8) and two known sesquiterpenoids (9 and 10). Their structures were identified by 1D and 2D NMR, HRESIMS, optical rotation, and chemical evidences. Compounds 1 and 8 exhibited dose-dependent inhibitory activity against β-catenin/TCF transcriptional activity.

本文言語	英語
ページ（範囲）	1501-1509
ページ数	9
ジャーナル	Heterocycles
巻	8
号	2
DOI	https://doi.org/10.3987/COM-13-S(S)49
出版ステータス	出版済み - 2014

ASJC Scopus 主題領域

分析化学
薬理学
有機化学

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10.3987/COM-13-S(S)49

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title = "Constituents from the rhizomes of Curcuma comosa and their Wnt signal inhibitory activities",

abstract = "Activity-guided fractionation of the Curcuma comosa rhizome MeOH extract that inhibited Wnt signal activity led to the characterization of two new diarylheptanoids (1 and 2) together with six known diarylheptanoids (3-8) and two known sesquiterpenoids (9 and 10). Their structures were identified by 1D and 2D NMR, HRESIMS, optical rotation, and chemical evidences. Compounds 1 and 8 exhibited dose-dependent inhibitory activity against β-catenin/TCF transcriptional activity.",

author = "Fuentes, {Rolly G.} and Kazufumi Toume and Arai, {Midori A.} and Takashi Koyano and Thaworn Kowithayakorn and Masami Ishibashi",

note = "Publisher Copyright: {\textcopyright} 2014 The Japan Institute of Heterocyclic Chemistry.",

year = "2014",

doi = "10.3987/COM-13-S(S)49",

language = "英語",

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T1 - Constituents from the rhizomes of Curcuma comosa and their Wnt signal inhibitory activities

AU - Fuentes, Rolly G.

AU - Toume, Kazufumi

AU - Arai, Midori A.

AU - Koyano, Takashi

AU - Kowithayakorn, Thaworn

AU - Ishibashi, Masami

PY - 2014

Y1 - 2014

N2 - Activity-guided fractionation of the Curcuma comosa rhizome MeOH extract that inhibited Wnt signal activity led to the characterization of two new diarylheptanoids (1 and 2) together with six known diarylheptanoids (3-8) and two known sesquiterpenoids (9 and 10). Their structures were identified by 1D and 2D NMR, HRESIMS, optical rotation, and chemical evidences. Compounds 1 and 8 exhibited dose-dependent inhibitory activity against β-catenin/TCF transcriptional activity.

AB - Activity-guided fractionation of the Curcuma comosa rhizome MeOH extract that inhibited Wnt signal activity led to the characterization of two new diarylheptanoids (1 and 2) together with six known diarylheptanoids (3-8) and two known sesquiterpenoids (9 and 10). Their structures were identified by 1D and 2D NMR, HRESIMS, optical rotation, and chemical evidences. Compounds 1 and 8 exhibited dose-dependent inhibitory activity against β-catenin/TCF transcriptional activity.

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U2 - 10.3987/COM-13-S(S)49

DO - 10.3987/COM-13-S(S)49

M3 - 学術論文

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SN - 0385-5414

VL - 8

SP - 1501

EP - 1509

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

Constituents from the rhizomes of Curcuma comosa and their Wnt signal inhibitory activities

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