Congenital contractural arachnodactyly without FBN1 or FBN2 gene mutations complicated by dilated cardiomyopathy

Hiroki Yagi, Masaru Hatano, Norifumi Takeda, Saori Harada, Yukari Suzuki, Yuki Taniguchi, Yukako Shintani, Hiroyuki Morita, Norio Kanamori, Takeshi Aoyama, Masafumi Watanabe, Ichiro Manabe, Hiroshi Akazawa, Koichiro Kinugawa, Issei Komuro*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

3 被引用数 (Scopus)

抄録

Congenital contractural arachnodactyly (CCA) is a rare connective tissue disorder characterized by marfanoid habitus with camptodactyly. However, cardiac features have rarely been documented in adults. We herein report a sporadic case of CCA in a 20-year-old woman who developed decompensated dilated cardiomyopathy. The patient did not have any mutations in the FBN1 or FBN2 genes, which are most commonly associated with Marfan syndrome and CCA, respectively. Although whether these two diseases are caused by a mutation(s) in the same gene or two different genes remains unknown, this case provides new clinical insight into the cardiovascular management of CCA.

本文言語英語
ページ(範囲)1237-1241
ページ数5
ジャーナルInternal Medicine
54
10
DOI
出版ステータス出版済み - 2015

ASJC Scopus 主題領域

  • 内科学

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