TY - JOUR
T1 - Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from citrus microcarpa
AU - Mori, Takahiro
AU - Shimokawa, Yoshihiko
AU - Matsui, Takashi
AU - Kinjo, Keishi
AU - Kato, Ryohei
AU - Noguchi, Hiroshi
AU - Sugio, Shigetoshi
AU - Morita, Hiroyuki
AU - Abe, Ikuro
PY - 2013/10/4
Y1 - 2013/10/4
N2 - Background:Type III polyketide synthases (PKSs) synthesize various polyketide and alkaloid scaffolds. Results:QNS synthesizes quinolone as the single product, whereas ACS produces acridone as the major product. Conclusion:QNS and ACS are novel quinolone- and acridone-producing type III PKSs, respectively. Significance:Structure-function analyses of QNS and ACS provide insights into molecular bases for alkaloid biosyntheses.
AB - Background:Type III polyketide synthases (PKSs) synthesize various polyketide and alkaloid scaffolds. Results:QNS synthesizes quinolone as the single product, whereas ACS produces acridone as the major product. Conclusion:QNS and ACS are novel quinolone- and acridone-producing type III PKSs, respectively. Significance:Structure-function analyses of QNS and ACS provide insights into molecular bases for alkaloid biosyntheses.
UR - http://www.scopus.com/inward/record.url?scp=84885111664&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.493155
DO - 10.1074/jbc.M113.493155
M3 - 学術論文
C2 - 23963450
AN - SCOPUS:84885111664
SN - 0021-9258
VL - 288
SP - 28845
EP - 28858
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 40
ER -