Clinical trials of stem cell therapy for cerebral ischemic stroke

Masahito Kawabori*, Hideo Shichinohe, Satoshi Kuroda, Kiyohiro Houkin

*この論文の責任著者

研究成果: ジャーナルへの寄稿総説査読

132 被引用数 (Scopus)

抄録

Despite recent developments in innovative treatment strategies, stroke remains one of the leading causes of death and disability worldwide. Stem cell therapy is currently attracting much attention due to its potential for exerting significant therapeutic effects on stroke patients. Various types of cells, including bone marrow mononuclear cells, bone marrow/adipose-derived stem/stromal cells, umbilical cord blood cells, neural stem cells, and olfactory ensheathing cells have enhanced neurological outcomes in animal stroke models. These stem cells have also been tested via clinical trials involving stroke patients. In this article, the authors review potential molecular mechanisms underlying neural recovery associated with stem cell treatment, as well as recent advances in stem cell therapy, with particular reference to clinical trials and future prospects for such therapy in treating stroke.

本文言語英語
論文番号7380
ページ(範囲)1-21
ページ数21
ジャーナルInternational Journal of Molecular Sciences
21
19
DOI
出版ステータス出版済み - 2020/10/01

ASJC Scopus 主題領域

  • 触媒
  • 分子生物学
  • 分光学
  • コンピュータ サイエンスの応用
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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