Clinical study of modulated electro-hyperthermia for advanced metastatic breast cancer

Takuya Nagata, Masahiko Kanamori*, Shinichi Sekine, Mie Arai, Makoto Moriyama, Tsutomu Fujii

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

7 被引用数 (Scopus)

抄録

Modulated electro-hyperthermia (mEHT) is a new treatment modality developed to overcome the problems associated with traditional hyperthermia; mEHT uses a precise impedance-matched system and modulated radiofrequency current flow to malignant tumors. It selects the malignant cells based on their biophysical differences, due to their high metabolic rate, individual (autonomic) behavior and membrane status. The aim of the present study was to report the outcomes of mEHT in the treatment of advanced breast cancer. mEHT was examined in 10 patients with advanced metastatic breast cancer and recurrent disease, who were considered incurable by standard therapy protocols. Of the 10 patients, partial response was achieved in 3, disease stability in 3, and progressive disease in 4; however, their quality of life was improved based on their subjective reports. No adverse effects were observed in any of the 10 patients. The present study demonstrated the feasibility of mEHT as a possible therapy for advanced breast cancer cases when standard therapies fail. Moreover, mEHT had no side effects and may be combined with various treat-ments for long-term therapy.

本文言語英語
論文番号103
ジャーナルMolecular and Clinical Oncology
14
5
DOI
出版ステータス出版済み - 2021

ASJC Scopus 主題領域

  • 腫瘍学
  • 癌研究

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