Circadian rhythm of histamine release from the hypothalamus of freely moving rats

Takatoshi Mochizuki*, Atsushi Yamatodani, Kaori Okakura, Arata Horii, Naoyuki Inagaki, Hiroshi Wada

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

161 被引用数 (Scopus)

抄録

Using an in vivo microdialysis technique coupled with HPLC-fluorometry, the release of neuronal histamine from the anterior hypothalamic area was monitored continuously in conscious, freely moving rats under a 12:12 h light:dark cycle. Spontaneous locomotor activity of the rats was measured simultaneously using a locomotor activity counter. Histamine release gradually increased in the second half of the light period (1400-2000) and the average histamine release during the dark period (2000-0800, 0.20±0.02 pmol/30 min) was significantly higher than that during the light period (0.12±0.01 pmol/30 min). This clear circadian change in the release suggests that the central histaminergic system is related to the circadian rhythm of rats.

本文言語英語
ページ(範囲)391-394
ページ数4
ジャーナルPhysiology and Behavior
51
2
DOI
出版ステータス出版済み - 1992/02

ASJC Scopus 主題領域

  • 実験心理学および認知心理学
  • 行動神経科学

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