Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice

Keyphrases

• Behavior Modification 100%
• Parkinson's Disease 100%
• Cause of Disease 100%
• Neurodegeneration 100%
• Parkin 100%
• SEPT4 100%
• Chronic Overload 100%
• Dopamine Neurons 75%
• Septin 75%
• Alpha-synuclein (α-syn) 50%
• Dysregulation 25%
• Behavioral Tests 25%
• No Significant Difference 25%
• Transgenic Mice 25%
• Attenuation 25%
• Neurotoxicity 25%
• Schizophrenia Symptoms 25%
• Bipolar Disorder 25%
• Mouse Brain 25%
• Littermate 25%
• Social Behavior 25%
• Tg Mouse 25%
• Histological Examination 25%
• Postmortem Brain 25%
• Behavioral Abnormalities 25%
• Gene Products 25%
• Pathogenicity 25%
• Loss Function 25%
• Nigrostriatal Dopamine 25%
• Lewy Bodies 25%
• Ubiquitin Ligase 25%
• Behavioral Paradigms 25%
• Long Genes 25%
• Dopamine Transporter 25%
• Voluntary Action 25%
• Associated Proteins 25%
• Viral Vectors 25%
• Neurodegenerative Processes 25%
• Autosomal Recessive Early-onset Parkinsonism 25%
• PARK2 25%
• Co-aggregate 25%
• Prion 25%
• Chronic Effects 25%

Neuroscience

• Parkinson's Disease 100%
• Neurodegeneration 100%
• Parkin 100%
• Septin 75%
• Synuclein 50%
• Behavioral Test 25%
• Neurotoxicity 25%
• Bipolar Disorder 25%
• Social Behavior 25%
• Promoter Region 25%
• Lewy Body 25%
• Virus Vector 25%
• Gene Product 25%
• Dopamine Transporter 25%
• Parkinsonism 25%
• Neurodegenerative Process 25%
• Ubiquitin Protein Ligase 25%
• Prion Protein 25%