Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity

Mai T.T. Nguyen; Khang D.H. Nguyen; Phu H. Dang; Hai X. Nguyen; Suresh Awale; Nhan T. Nguyen

doi:10.1021/acs.jnatprod.9b00875

Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity

Mai T.T. Nguyen, Khang D.H. Nguyen, Phu H. Dang, Hai X. Nguyen, Suresh Awale^*, Nhan T. Nguyen

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

23 被引用数 (Scopus)

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Phytochemical analysis of the roots of Calotropis gigantea led to the isolation of six new cardenolide glycosides, calosides A-F (1-6), and five known cardenolides (7-11). The structures of 1-6 were elucidated based on NMR and ECD spectroscopic data interpretation. Caloside D (4) is the first naturally occurring example of a cardenolide containing a C-8/C-19 oxygen bridge. In turn, calosides E (5) and F (6) represent the first naturally occurring 3-epi-cannogenol diglycosides having potent cytotoxicity against the PANC-1 cell line (IC₅₀, 0.081 and 0.070 μM, respectively) and HeLa (IC₅₀, both 0.17 μM) cells, under normoglycemic conditions.

本文言語	英語
ページ（範囲）	385-391
ページ数	7
ジャーナル	Journal of Natural Products
巻	83
号	2
DOI	https://doi.org/10.1021/acs.jnatprod.9b00875
出版ステータス	出版済み - 2020/02/28

ASJC Scopus 主題領域

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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10.1021/acs.jnatprod.9b00875

引用スタイル

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title = "Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity",

abstract = "Phytochemical analysis of the roots of Calotropis gigantea led to the isolation of six new cardenolide glycosides, calosides A-F (1-6), and five known cardenolides (7-11). The structures of 1-6 were elucidated based on NMR and ECD spectroscopic data interpretation. Caloside D (4) is the first naturally occurring example of a cardenolide containing a C-8/C-19 oxygen bridge. In turn, calosides E (5) and F (6) represent the first naturally occurring 3-epi-cannogenol diglycosides having potent cytotoxicity against the PANC-1 cell line (IC50, 0.081 and 0.070 μM, respectively) and HeLa (IC50, both 0.17 μM) cells, under normoglycemic conditions.",

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note = "Publisher Copyright: Copyright {\textcopyright} 2020 American Chemical Society and American Society of Pharmacognosy.",

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T1 - Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity

AU - Nguyen, Mai T.T.

AU - Nguyen, Khang D.H.

AU - Dang, Phu H.

AU - Nguyen, Hai X.

AU - Awale, Suresh

AU - Nguyen, Nhan T.

PY - 2020/2/28

Y1 - 2020/2/28

N2 - Phytochemical analysis of the roots of Calotropis gigantea led to the isolation of six new cardenolide glycosides, calosides A-F (1-6), and five known cardenolides (7-11). The structures of 1-6 were elucidated based on NMR and ECD spectroscopic data interpretation. Caloside D (4) is the first naturally occurring example of a cardenolide containing a C-8/C-19 oxygen bridge. In turn, calosides E (5) and F (6) represent the first naturally occurring 3-epi-cannogenol diglycosides having potent cytotoxicity against the PANC-1 cell line (IC50, 0.081 and 0.070 μM, respectively) and HeLa (IC50, both 0.17 μM) cells, under normoglycemic conditions.

AB - Phytochemical analysis of the roots of Calotropis gigantea led to the isolation of six new cardenolide glycosides, calosides A-F (1-6), and five known cardenolides (7-11). The structures of 1-6 were elucidated based on NMR and ECD spectroscopic data interpretation. Caloside D (4) is the first naturally occurring example of a cardenolide containing a C-8/C-19 oxygen bridge. In turn, calosides E (5) and F (6) represent the first naturally occurring 3-epi-cannogenol diglycosides having potent cytotoxicity against the PANC-1 cell line (IC50, 0.081 and 0.070 μM, respectively) and HeLa (IC50, both 0.17 μM) cells, under normoglycemic conditions.

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Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity

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