Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity

Mai T.T. Nguyen, Khang D.H. Nguyen, Phu H. Dang, Hai X. Nguyen, Suresh Awale*, Nhan T. Nguyen

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

23 被引用数 (Scopus)

抄録

Phytochemical analysis of the roots of Calotropis gigantea led to the isolation of six new cardenolide glycosides, calosides A-F (1-6), and five known cardenolides (7-11). The structures of 1-6 were elucidated based on NMR and ECD spectroscopic data interpretation. Caloside D (4) is the first naturally occurring example of a cardenolide containing a C-8/C-19 oxygen bridge. In turn, calosides E (5) and F (6) represent the first naturally occurring 3-epi-cannogenol diglycosides having potent cytotoxicity against the PANC-1 cell line (IC50, 0.081 and 0.070 μM, respectively) and HeLa (IC50, both 0.17 μM) cells, under normoglycemic conditions.

本文言語英語
ページ(範囲)385-391
ページ数7
ジャーナルJournal of Natural Products
83
2
DOI
出版ステータス出版済み - 2020/02/28

ASJC Scopus 主題領域

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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