Bis-iridoid and iridoid glycosides: Viral protein R inhibitors from Picrorhiza kurroa collected in Myanmar

Nwet Nwet Win*, Takeshi Kodama, Khine Zar Wynn Lae, Yi Yi Win, Hla Ngwe, Ikuro Abe, Hiroyuki Morita

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

34 被引用数 (Scopus)

抄録

Four new bis-iridoid glycosides, saungmaygaosides A-D (1–4), and six known iridoid glycosides (5–10) were isolated from the n-butanol extract of the stems of Picrorhiza kurroa collected in Myanmar. Their structures were elucidated by extensive spectroscopic techniques. All of the isolates were assayed for anti-Vpr activity, using TREx-HeLa-Vpr cells. Among the isolates, saungmaygaoside D (4), sylvestroside IV dimethyl acetal (7), and sweroside (8) were the most potent inhibitors with effective doses of 5 and 10 μM, respectively, without showing any notable cytotoxicities.

本文言語英語
ページ(範囲)101-107
ページ数7
ジャーナルFitoterapia
134
DOI
出版ステータス出版済み - 2019/04

ASJC Scopus 主題領域

  • 薬理学
  • 創薬

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