@article{ee4a35b1eb37448dbaa7b176aeedcc49,
title = "BDNF and NT-3 modulate expression and threonine phosphorylation of microtubule-associated protein 2 analogues, and alter their distribution in the developing rat cerebral cortex",
abstract = "Effects of brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-3 on the expression of structural or synapse-associated proteins were examined in the developing rat cerebral cortex. Following ventricular administration of BDNF or NT-3 at embryonic day (E) 16, expression of microtubule-associated protein (MAP) 2 of 280 kDa was enhanced at E18 and/or E20, and threonine phosphorylation of MAP2 analogues of 120 and 66 kDa was modulated in different ways. NT-3 basically altered the distribution of MAP2 proteins at E20. These findings suggest that NT-3 and BDNF play a role in regulating production and phosphorylation of MAP2 analogues during development of the rat cerebral cortex.",
keywords = "Brain development, Brain-derived neurotrophic factor (BDNF), Microtubule-associated protein 2, Neurotrophin- 3 (NT-3), Phosphorylation, Ventricular administration",
author = "Hidefumi Fukumitsu and Akiko Ohashi and Atsumi Nitta and Hiroshi Nomoto and Shoei Furukawa",
note = "Funding Information: This work was supported by a grant from the program Grants-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, and Culture of Japan. ",
year = "1997",
month = dec,
day = "5",
doi = "10.1016/S0304-3940(97)00852-5",
language = "英語",
volume = "238",
pages = "107--110",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",
}