Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development

Seiichi Koike, Yoshifumi Yutoh, Kazuko Keino-Masu, Sumihare Noji, Masayuki Masu*, Hideyo Ohuchi

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

32 被引用数 (Scopus)

抄録

Autotaxin (ATX) is a lysophospholipid-generating exoenzyme expressed in embryonic and adult neural tissues. We previously showed that ATX is expressed in the neural organizing centers, anterior head process, and midbrain-hindbrain boundary (MHB). To elucidate the role of ATX during neural development, here we examined the neural phenotypes of ATX-deficient mice. Expression analysis of neural marker genes revealed that lateral expansion of the rostral forebrain is reduced and establishment of the MHB is compromised as early as the late headfold stage in ATX mutant embryos. Moreover, ATX mutant embryos fail to complete cranial neural tube closure. These results indicate that ATX is essential for cranial neurulation and MHB establishment.

本文言語英語
ページ(範囲)413-421
ページ数9
ジャーナルDevelopmental Dynamics
240
2
DOI
出版ステータス出版済み - 2011/02

ASJC Scopus 主題領域

  • 発生生物学

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