TY - JOUR
T1 - Autoimmune features in metabolic liver disease
T2 - A single-center experience and review of the literature
AU - Tsuneyama, Koichi
AU - Baba, Hayato
AU - Kikuchi, Kentaro
AU - Nishida, Takeshi
AU - Nomoto, Kazuhiro
AU - Hayashi, Shinichi
AU - Miwa, Shigeharu
AU - Nakajima, Takahiko
AU - Nakanishi, Yuko
AU - Masuda, Shinji
AU - Terada, Mitsuhiro
AU - Imura, Johji
AU - Selmi, Carlo
N1 - Funding Information:
Acknowledgments The authors are thankful to Mr. Tokimasa Kumada and Mr. Hideki Hatta for their help and technical assistance with experiments and to Ms. Yukari Inoue for the excellent support in the manuscript preparation. This work was supported by JSPS KAKENHI Grant Numbers 0293341 and 10293341 and a Research grant of 2010 Takeda Science Foundation.
PY - 2013/8
Y1 - 2013/8
N2 - Non-alcoholic steatohepatitis (NASH) is the progressive phenotype of non-alcoholic fatty liver disease associated with the metabolic syndrome. The existence of autoimmune features in NASH has been reported, but its significance remains unclear. We herein report the autoantibody profile of 54 patients with histologically proven NASH and further determined the development of autoimmunity in three different murine NASH models (monosodium glutamate, CDAA (choline-deficient l-amino acid-defined), and TSOD (Tsumura Suzuki, Obese Diabetes)) at 48 weeks of age. Forty-eight percent (26/54) of NASH cases were positive for antinuclear (ANA) or antimitochondrial antibody and manifested histological signs of overlap with autoimmune hepatitis and primary biliary cirrhosis, respectively. These patients were significantly older (60 ± 10 versus 50 ± 16 years), more frequently women (81 % versus 43 %), and with more severe portal inflammatory infiltrate compared with patients without autoimmunity. In one third of mice, regardless of the model, we observed a marked lymphoid infiltrate with non-suppurative cholangitis, and several cases were ANA-positive, but none AMA-positive. Our data suggest that autoimmunity may share some pathogenetic traits with the chronic inflammation of NASH, possibly related to advanced age.
AB - Non-alcoholic steatohepatitis (NASH) is the progressive phenotype of non-alcoholic fatty liver disease associated with the metabolic syndrome. The existence of autoimmune features in NASH has been reported, but its significance remains unclear. We herein report the autoantibody profile of 54 patients with histologically proven NASH and further determined the development of autoimmunity in three different murine NASH models (monosodium glutamate, CDAA (choline-deficient l-amino acid-defined), and TSOD (Tsumura Suzuki, Obese Diabetes)) at 48 weeks of age. Forty-eight percent (26/54) of NASH cases were positive for antinuclear (ANA) or antimitochondrial antibody and manifested histological signs of overlap with autoimmune hepatitis and primary biliary cirrhosis, respectively. These patients were significantly older (60 ± 10 versus 50 ± 16 years), more frequently women (81 % versus 43 %), and with more severe portal inflammatory infiltrate compared with patients without autoimmunity. In one third of mice, regardless of the model, we observed a marked lymphoid infiltrate with non-suppurative cholangitis, and several cases were ANA-positive, but none AMA-positive. Our data suggest that autoimmunity may share some pathogenetic traits with the chronic inflammation of NASH, possibly related to advanced age.
KW - Female sex
KW - Metabolic syndrome
KW - Non-alcoholic fatty liver disease
UR - http://www.scopus.com/inward/record.url?scp=84880775381&partnerID=8YFLogxK
U2 - 10.1007/s12016-013-8383-x
DO - 10.1007/s12016-013-8383-x
M3 - 総説
C2 - 23842720
AN - SCOPUS:84880775381
SN - 1080-0549
VL - 45
SP - 143
EP - 148
JO - Clinical Reviews in Allergy and Immunology
JF - Clinical Reviews in Allergy and Immunology
IS - 1
ER -
