Association between olfactory sulcus morphology and olfactory functioning in schizophrenia and psychosis high-risk status

Tsutomu Takahashi*, Mihoko Nakamura, Daiki Sasabayashi, Yumiko Nishikawa, Yoichiro Takayanagi, Atsushi Furuichi, Mikio Kido, Yuko Mizukami, Shimako Nishiyama, Yuko Higuchi, Takahiro Tateno, Hiroko Itoh, Kyo Noguchi, Yuri Masaoka, Michio Suzuki

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

9 被引用数 (Scopus)

抄録

Olfactory impairment has been reported in patients with schizophrenia and individuals with a high risk of psychosis, but its neural basis is largely unknown. We used magnetic resonance imaging to investigate the morphology of the olfactory sulcus (an indicator of olfactory system development) and its relation to olfactory function in 38 persons with an at-risk mental state (ARMS), 62 patients with schizophrenia, and 61 healthy controls. Odor detection and identification were examined with a T & T olfactometer. Compared with the controls, the olfactory sulcus was significantly shallower and odor identification was inferior among the ARMS and schizophrenia subjects. Across all subjects, but not within each group, the olfactory sulcus depth was significantly related to better identification of odors. Our results support the concept that olfactory sulcus morphology reflects the neurodevelopmental process of the olfactory system.

本文言語英語
論文番号e02642
ジャーナルHeliyon
5
10
DOI
出版ステータス出版済み - 2019/10

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