Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay

Jung Bum Lee*, Kyoko Hayashi, Megumi Hirata, Eiko Kuroda, Eiko Suzuki, Yoshihiro Kubo, Toshimitsu Hayashi

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

134 被引用数 (Scopus)

抄録

A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa (W. SMITH) RALFS, collected in deep sea water from Toyama Bay. The polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. It showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices (CC50/IC50) of 270, 510 and 32, respectively. Naviculan also showed an inhibitory effect on cell-cell fusion between CD4-expressing and human immunodeficiency virus (HIV) gp160-expressing cells that was used as a model system of infection with HIV.

本文言語英語
ページ(範囲)2135-2139
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
29
10
DOI
出版ステータス出版済み - 2006

ASJC Scopus 主題領域

  • 薬理学
  • 薬科学

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