Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay

Jung Bum Lee; Kyoko Hayashi; Megumi Hirata; Eiko Kuroda; Eiko Suzuki; Yoshihiro Kubo; Toshimitsu Hayashi

doi:10.1248/bpb.29.2135

Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay

Jung Bum Lee^*, Kyoko Hayashi, Megumi Hirata, Eiko Kuroda, Eiko Suzuki, Yoshihiro Kubo, Toshimitsu Hayashi

^*この論文の責任著者

植物機能科学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

134 被引用数 (Scopus)

抄録

A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa (W. SMITH) RALFS, collected in deep sea water from Toyama Bay. The polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. It showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices (CC₅₀/IC₅₀) of 270, 510 and 32, respectively. Naviculan also showed an inhibitory effect on cell-cell fusion between CD4-expressing and human immunodeficiency virus (HIV) gp160-expressing cells that was used as a model system of infection with HIV.

本文言語	英語
ページ（範囲）	2135-2139
ページ数	5
ジャーナル	Biological and Pharmaceutical Bulletin
巻	29
号	10
DOI	https://doi.org/10.1248/bpb.29.2135
出版ステータス	出版済み - 2006

ASJC Scopus 主題領域

薬理学
薬科学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1248/bpb.29.2135

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title = "Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay",

abstract = "A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa (W. SMITH) RALFS, collected in deep sea water from Toyama Bay. The polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. It showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices (CC50/IC50) of 270, 510 and 32, respectively. Naviculan also showed an inhibitory effect on cell-cell fusion between CD4-expressing and human immunodeficiency virus (HIV) gp160-expressing cells that was used as a model system of infection with HIV.",

keywords = "Antiviral activity, Deep sea water, Diatom, Navicula directa, Polysaccharide",

author = "Lee, {Jung Bum} and Kyoko Hayashi and Megumi Hirata and Eiko Kuroda and Eiko Suzuki and Yoshihiro Kubo and Toshimitsu Hayashi",

year = "2006",

doi = "10.1248/bpb.29.2135",

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T1 - Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay

AU - Lee, Jung Bum

AU - Hayashi, Kyoko

AU - Hirata, Megumi

AU - Kuroda, Eiko

AU - Suzuki, Eiko

AU - Kubo, Yoshihiro

AU - Hayashi, Toshimitsu

PY - 2006

Y1 - 2006

N2 - A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa (W. SMITH) RALFS, collected in deep sea water from Toyama Bay. The polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. It showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices (CC50/IC50) of 270, 510 and 32, respectively. Naviculan also showed an inhibitory effect on cell-cell fusion between CD4-expressing and human immunodeficiency virus (HIV) gp160-expressing cells that was used as a model system of infection with HIV.

AB - A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa (W. SMITH) RALFS, collected in deep sea water from Toyama Bay. The polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. It showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices (CC50/IC50) of 270, 510 and 32, respectively. Naviculan also showed an inhibitory effect on cell-cell fusion between CD4-expressing and human immunodeficiency virus (HIV) gp160-expressing cells that was used as a model system of infection with HIV.

KW - Antiviral activity

KW - Deep sea water

KW - Diatom

KW - Navicula directa

KW - Polysaccharide

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U2 - 10.1248/bpb.29.2135

DO - 10.1248/bpb.29.2135

M3 - 学術論文

C2 - 17015966

AN - SCOPUS:33749444436

SN - 0918-6158

VL - 29

SP - 2135

EP - 2139

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 10

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Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay

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ASJC Scopus 主題領域

UN SDG

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