抄録
A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa (W. SMITH) RALFS, collected in deep sea water from Toyama Bay. The polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. It showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices (CC50/IC50) of 270, 510 and 32, respectively. Naviculan also showed an inhibitory effect on cell-cell fusion between CD4-expressing and human immunodeficiency virus (HIV) gp160-expressing cells that was used as a model system of infection with HIV.
本文言語 | 英語 |
---|---|
ページ(範囲) | 2135-2139 |
ページ数 | 5 |
ジャーナル | Biological and Pharmaceutical Bulletin |
巻 | 29 |
号 | 10 |
DOI | |
出版ステータス | 出版済み - 2006 |
ASJC Scopus 主題領域
- 薬理学
- 薬科学