Anti-metastatic effects of baicalein by targeting STAT3 activity in breast cancer cells

Gorrepotu Dani Susmitha, Kiho Miyazato, Keisuke Ogura, Satoru Yokoyama, Yoshihiro Hayakawa*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

22 被引用数 (Scopus)

抄録

Signal transducer and activator of transcription 3 (STAT3) is considered a potential target for cancer treatment because of its relationship with cellular transformation and tumor initiation and progression. In this study, we aimed to identify a new anti-cancer drug candidate from natural products by targeting STAT3 activity. Using STAT3-luciferase reporter cell line, we screened the chemical library of natural products and found that baicalein, a flavone isolated from the roots of Scutelleria baicalensis, strongly suppressed STAT3 activity in breast cancer cells. Baicalein inhibited STAT3 transcriptional activity and its phosphorylation, and further exhibited anti-proliferative effects in breast cancer cells. Moreover, baicalein suppressed the production of interleukin (IL)-6 and the metastatic potential of breast cancer cells both in vitro and in vivo. Collectively, our study suggests baicalein as an attractive phytochemical compound for reducing metastatic potential of breast cancer cells by regulating STAT3 activity.

本文言語英語
ページ(範囲)1899-1905
ページ数7
ジャーナルBiological and Pharmaceutical Bulletin
43
12
DOI
出版ステータス出版済み - 2020/12/01

ASJC Scopus 主題領域

  • 薬理学
  • 薬科学

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