Anti-herpes simplex virus target of an acidic polysaccharide, nostoflan, from the edible blue-green alga Nostoc flagelliforme

Kenji Kanekiyo, Kyoko Hayashi, Hiroyuki Takenaka, Jung Bum Lee, Toshimitsu Hayashi*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

121 被引用数 (Scopus)

抄録

The acidic polysaccharide nostoflan was previously isolated as an antiviral component from the terrestrial alga Nostoc flagelliforme. In the present study, we examined the target for its anti-herpes simplex virus type 1 action. In time-of-addition experiments, the most sensitive stage of viral replication to nostoflan was found to be early events, including the virus binding and/or penetration processes. In order to determine what extent nostoflan may be involved in these processes, virus binding and penetration assays were separately performed. The results indicated that the inhibition of virus binding to but not penetration into host cells was responsible for the antiherpetic effect induced by nostoflan. Our study suggests that nostoflan may be a potential antiherpes agent.

本文言語英語
ページ(範囲)1573-1575
ページ数3
ジャーナルBiological and Pharmaceutical Bulletin
30
8
DOI
出版ステータス出版済み - 2007/08

ASJC Scopus 主題領域

  • 薬理学
  • 薬科学

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