抄録
An efficient synthesis of cyclohexane- and cyclopentane-1,3-dione-2-spirocyclopropanes from 1,3-cycloalkanediones using sulfonium salts was achieved. The reaction of 1,3-cycloalkanediones with (1-aryl-2-bromoethyl)-dimethylsulfonium bromides and powdered K2CO3 in EtOAc provided the corresponding spirocyclopropanes in high yields. Furthermore, a one-pot synthesis of tetrahydroindol-4(5H)-one from 1,3-cyclohexanedione was achieved using the present protocol and a sequential ring-opening cyclization of spirocyclopropane with a primary amine.
本文言語 | 英語 |
---|---|
ページ(範囲) | 4312-4315 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 56 |
号 | 29 |
DOI | |
出版ステータス | 出版済み - 2015/06/14 |
ASJC Scopus 主題領域
- 生化学
- 創薬
- 有機化学