An efficient methodology for the C-C bond forming radical cyclization of hydrophobic substrates in water: Effect of additive on radical reaction in water

Hisanori Nambu; Gopinathan Anilkumar; Masato Matsugi; Yasuyuki Kita

doi:10.1016/S0040-4020(02)01448-5

An efficient methodology for the C-C bond forming radical cyclization of hydrophobic substrates in water: Effect of additive on radical reaction in water

Hisanori Nambu, Gopinathan Anilkumar, Masato Matsugi, Yasuyuki Kita^*

^*この論文の責任著者

分子合成化学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

52 被引用数 (Scopus)

抄録

The combination of the water-soluble radical initiator, 2,2′-azobis[2-(2-imidazolin-2-yl)propane] (VA-061), water-soluble chain carrier, 1-ethylpiperidine hypophosphite (EPHP) and surfactant, cetyltrimethylammonium bromide (CTAB), was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates. The effect of additives and surfactant in the radical cyclization reaction in water was also investigated.

本文言語	英語
ページ（範囲）	77-85
ページ数	9
ジャーナル	Tetrahedron
巻	59
号	1
DOI	https://doi.org/10.1016/S0040-4020(02)01448-5
出版ステータス	出版済み - 2003/01/01

ASJC Scopus 主題領域

生化学
創薬
有機化学

文献へのアクセス

10.1016/S0040-4020(02)01448-5

フィンガープリント

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引用スタイル

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title = "An efficient methodology for the C-C bond forming radical cyclization of hydrophobic substrates in water: Effect of additive on radical reaction in water",

abstract = "The combination of the water-soluble radical initiator, 2,2′-azobis[2-(2-imidazolin-2-yl)propane] (VA-061), water-soluble chain carrier, 1-ethylpiperidine hypophosphite (EPHP) and surfactant, cetyltrimethylammonium bromide (CTAB), was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates. The effect of additives and surfactant in the radical cyclization reaction in water was also investigated.",

keywords = "C-C bond, Cetyltrimethylammonium bromide, Radical reactions",

author = "Hisanori Nambu and Gopinathan Anilkumar and Masato Matsugi and Yasuyuki Kita",

note = "Funding Information: This work was supported by Grants-in-Aid for Scientific Research (S) (No. 13853010), for Scientific Research on Priority Area (A) (No. 13029062) from the Ministry of Education, Science, Sports, and Culture, Japan and the Takeda Science Foundation, Japan. We thank Wako Pure Chemical Industries, Ltd., for the generous supply of several water-soluble azo-type initiators. G. A. thanks the Japan Society for the Promotion of Science (JSPS) for a postdoctoral fellowship.",

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doi = "10.1016/S0040-4020(02)01448-5",

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AU - Matsugi, Masato

AU - Kita, Yasuyuki

N1 - Funding Information: This work was supported by Grants-in-Aid for Scientific Research (S) (No. 13853010), for Scientific Research on Priority Area (A) (No. 13029062) from the Ministry of Education, Science, Sports, and Culture, Japan and the Takeda Science Foundation, Japan. We thank Wako Pure Chemical Industries, Ltd., for the generous supply of several water-soluble azo-type initiators. G. A. thanks the Japan Society for the Promotion of Science (JSPS) for a postdoctoral fellowship.

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N2 - The combination of the water-soluble radical initiator, 2,2′-azobis[2-(2-imidazolin-2-yl)propane] (VA-061), water-soluble chain carrier, 1-ethylpiperidine hypophosphite (EPHP) and surfactant, cetyltrimethylammonium bromide (CTAB), was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates. The effect of additives and surfactant in the radical cyclization reaction in water was also investigated.

AB - The combination of the water-soluble radical initiator, 2,2′-azobis[2-(2-imidazolin-2-yl)propane] (VA-061), water-soluble chain carrier, 1-ethylpiperidine hypophosphite (EPHP) and surfactant, cetyltrimethylammonium bromide (CTAB), was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates. The effect of additives and surfactant in the radical cyclization reaction in water was also investigated.

KW - C-C bond

KW - Cetyltrimethylammonium bromide

KW - Radical reactions

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